Design of antisense oligonucleotides stabilized by locked nucleic acids.
about
Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypesMethodological obstacles in knocking down small noncoding RNAsChimeric RNase H-competent oligonucleotides directed to the HIV-1 Rev response elementLocked nucleic acid (LNA) mediated improvements in siRNA stability and functionalityThe influence of locked nucleic acid residues on the thermodynamic properties of 2'-O-methyl RNA/RNA heteroduplexesIntercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities.Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAsAdvanced In vivo Use of CRISPR/Cas9 and Anti-sense DNA Inhibition for Gene Manipulation in the BrainTherapeutic Oligonucleotides Targeting Liver Disease: TTR AmyloidosisA regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplexA lncRNA Perspective into (Re)Building the HeartHsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activityAntisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice.Oxetane locked thymidine in the Dickerson-Drew dodecamer causes local base pairing distortions -- an NMR structure and hydration study.Exploring cellular activity of locked nucleic acid-modified triplex-forming oligonucleotides and defining its molecular basis.Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites.Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNADesign and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro.Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice.RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primatesRNA interference functions as an antiviral immunity mechanism in mammals.Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behaviorAntisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera designA sensitive assay system to test antisense oligonucleotides for splice suppression therapy in the mouse liver.Amplification and re-generation of LNA-modified libraries.Contributions of stacking, preorganization, and hydrogen bonding to the thermodynamic stability of duplexes between RNA and 2'-O-methyl RNA with locked nucleic acids.Regulation of microRNA-mediated gene silencing by microRNA precursors.Improved in situ hybridization efficiency with locked-nucleic-acid-incorporated DNA probes.Targeting chromosomal sites with locked nucleic acid-modified triplex-forming oligonucleotides: study of efficiency dependence on DNA nuclear environment.The potential of antisense as a CNS therapeutic.Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes.RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications.Correlating In Vitro Splice Switching Activity With Systemic In Vivo Delivery Using Novel ZEN-modified Oligonucleotides.DNA and RNA derivatives to optimize distribution and deliverymRNA fragments in in vitro culture media are associated with bovine preimplantation embryonic development.Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers.Coxsackievirus-induced myocarditis: new trends in treatment.Male fertility status is associated with DNA methylation signatures in sperm and transcriptomic profiles of bovine preimplantation embryos
P2860
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P2860
Design of antisense oligonucleotides stabilized by locked nucleic acids.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Design of antisense oligonucleotides stabilized by locked nucleic acids.
@en
Design of antisense oligonucleotides stabilized by locked nucleic acids.
@nl
type
label
Design of antisense oligonucleotides stabilized by locked nucleic acids.
@en
Design of antisense oligonucleotides stabilized by locked nucleic acids.
@nl
prefLabel
Design of antisense oligonucleotides stabilized by locked nucleic acids.
@en
Design of antisense oligonucleotides stabilized by locked nucleic acids.
@nl
P2093
P2860
P356
P1476
Design of antisense oligonucleotides stabilized by locked nucleic acids.
@en
P2093
Clemens Gillen
Jens Kurreck
Volker A Erdmann
P2860
P304
P356
10.1093/NAR/30.9.1911
P407
P50
P577
2002-05-01T00:00:00Z