Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
about
Targeting the Bcl-2 family for cancer therapyTargeting Mcl-1 for the therapy of cancerLa FAM fatale: USP9X in development and diseaseDeubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagyNaturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating EnzymesAntiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein responseA small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA virusesUSP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma.Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosisContext-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinomaBAG1: the guardian of anti-apoptotic proteins in acute myeloid leukemia.The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses.Reduced ubiquitin-specific protease 9X expression induced by RNA interference inhibits the bioactivity of hepatocellular carcinoma cellsDeubiquitinases in cancer.Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9.Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxideAblation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutationsDeubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth.The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins.Development of an effective therapy for chronic myelogenous leukemiaOncoapoptotic markers in oral cancer: prognostics and therapeutic perspective.Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Degrasyn-like symmetrical compounds: possible therapeutic agents for multiple myeloma (MM-I).Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes.Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors.Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents.Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth.Targeting oncoproteins for degradation by small molecules in myeloid leukemia.Deubiquitylating enzymes and drug discovery: emerging opportunities.Profiling the Activity of Deubiquitinating Enzymes Using Chemically Synthesized Ubiquitin-Based Probes.Decreased expression of USP9X is associated with poor prognosis in Chinese pancreatic ductal adenocarcinoma patients.Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug repositionDeubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction
P2860
Q26866936-F3047110-C08A-4EDE-86D6-1CA9F43A1C13Q27011870-2D861FEF-7462-4A39-96FB-3041184D2F71Q27025293-1747BEC5-8D6B-497C-9A84-E13330AC275AQ27311286-03C69940-99B1-4049-A369-AED41A47D29DQ28269486-230C211C-C7D8-4247-9ABE-18EF432D9A48Q28481001-46B6E5D9-7BC7-4131-80FF-384B8800776EQ28504988-44D55359-6B01-4281-B92B-E400651BF272Q28537731-A86634CB-0817-40DD-B2AD-4D47ABE95E53Q33592884-4AC44F92-DD06-4CEF-B5DE-F4511A8539C1Q33851111-E79E4999-5FDE-4DBA-B217-29C599EB4D96Q33989933-BA1ED89D-6C79-4F1E-8C9E-38F3013619C6Q34053504-548132DA-85FB-4077-9ECE-C852012342C2Q34484344-F97FFCE3-831F-43F8-9F98-A02DE156FBBBQ34722352-A44BCDC8-6595-4D45-953C-7C38334CD230Q35803778-D343F275-B0B5-4ED2-8F55-F08B22BB86FAQ35955141-0D55DEC8-CD2A-4D98-A177-7F73ADF39E30Q36006797-901CF635-DFE6-48F2-9E03-09BEE8C5D099Q36036234-5FA8D5D0-1A38-48A6-9D35-D49627B90672Q36068851-19513404-7C3A-4D5D-A6FD-6845CFB1DA7AQ36352545-36CD69A7-18C3-4A23-B63E-D6D09C4BD3DEQ37660030-532019F2-7213-47A9-A61A-688186E1589FQ37662261-BF3C5976-0656-48C6-AF15-BF061C4F3D30Q37694810-886B7D40-30DA-47EE-AD5B-1D56DC56287BQ37702614-E2A5F062-9E5D-463F-A28D-1290B1D7116DQ37966917-A1BC577C-B7DA-4498-93D2-30989C44015EQ38212609-694D6FEF-48F0-4B3E-947F-4458F09073FFQ38695071-DCE0C72A-3ADF-4F2E-95B7-049D8399AA48Q38943401-D03D40CE-2BCF-48D7-88DE-37D87C1B0991Q38989377-EDFBB158-7CD1-4AF5-8B36-FC3E5860563BQ39031307-3AA57042-E5AE-4E45-99F5-BD7702CA49BCQ39271369-B95984CC-8263-41D1-9378-59BECDB71BC8Q41907705-27963C32-217D-44F8-A521-50329F40F913Q47098444-8CFBFF9A-954E-4060-836C-E4B39A65C0B2Q47150678-84A19874-3740-4881-BD9D-64F73668EF0CQ47337952-6D9633FF-F110-42F6-8435-97F6417F4085Q48265884-584B789B-1925-41EA-BD9B-EFBF13B4C607Q51364802-1DD0611A-E067-4E22-A09D-EAD66B977C30Q55168459-1C994FE2-5766-4620-88E2-891B71C96708Q57163862-BCF5C271-217A-4776-A7A2-A364820CE666Q58774942-FAF64B13-4231-4F35-8D24-564E1EB41095
P2860
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Bcr-Abl ubiquitination and Usp ...... nd promote CML cell apoptosis.
@en
Bcr-Abl ubiquitination and Usp ...... nd promote CML cell apoptosis.
@nl
type
label
Bcr-Abl ubiquitination and Usp ...... nd promote CML cell apoptosis.
@en
Bcr-Abl ubiquitination and Usp ...... nd promote CML cell apoptosis.
@nl
prefLabel
Bcr-Abl ubiquitination and Usp ...... nd promote CML cell apoptosis.
@en
Bcr-Abl ubiquitination and Usp ...... nd promote CML cell apoptosis.
@nl
P2093
P1433
P1476
Bcr-Abl ubiquitination and Usp ...... nd promote CML cell apoptosis.
@en
P2093
Dexing Fang
Geoffrey Bartholomeusz
Hanshi Sun
Luke F Peterson
Moshe Talpaz
Nicholas J Donato
Vaibhav Kapuria
William G Bornmann
P304
P356
10.1182/BLOOD-2010-03-276477
P407
P577
2011-01-19T00:00:00Z