Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
about
Cullin-RING ubiquitin ligases: global regulation and activation cyclesp62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcriptionCysteine-based regulation of the CUL3 adaptor protein Keap1Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant responsePhysiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activityMolecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease interventionThe spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergeticsOverview of Nrf2 as Therapeutic Target in EpilepsyAntioxidant responses and cellular adjustments to oxidative stressThe Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseasesRegulation of Drosophila metamorphosis by xenobiotic response regulatorsThe C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expressionDifferent Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress ResponseStructural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin LigasesKinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1Toxicity testing in the 21st century: a vision and a strategyDietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agentsCullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resectionNegative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulumBood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferaseNuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung FibrosisCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersPGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondriaStress-activated cap'n'collar transcription factors in aging and human diseaseCACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosisSmall molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsArsenic-mediated activation of the Nrf2-Keap1 antioxidant pathwayThe complexity of the Nrf2 pathway: beyond the antioxidant responseBasic principles and emerging concepts in the redox control of transcription factorsp62 links autophagy and Nrf2 signalingMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseEmerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotectionMechanism of chemical activation of Nrf2HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agentsActinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathwayMacrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element SystemDual NRF2 paralogs in Coho salmon and their antioxidant response element targetsProspective type 1 and type 2 disulfides of Keap1 protein.
P2860
Q21203558-AED12CA4-BE13-43E1-ACF4-9A2213FAE0C7Q24310885-5774AEDE-7A12-4BD5-B3F1-F4037BDBE911Q24629359-416A6F0A-B400-4E7F-8109-948927D89613Q24646029-BBF69AC9-CFD7-45D6-BF71-B419DBFED954Q24655442-780471D5-4B6B-481F-8407-F98199784D5EQ26778356-9948CDC7-C4C0-41B4-8D6A-20750791611EQ26778368-41886582-60AF-4A0B-A04D-B61B36E5E4EFQ26799344-EE948F8E-B505-4644-856E-BFD319E084DBQ26800229-128666EC-70CB-4A6E-B662-50BC390C59E7Q26822972-D4C9BBA5-0C73-42DB-A3C2-24DA95088379Q27324641-1095FC06-F191-4611-84D9-F459B0025C56Q27341433-DC7ACDAC-5063-484F-A938-0B46BC1EB301Q27647812-F4B96FFA-7EA9-431F-8F4C-320F8BC79C20Q27675990-27B75C8C-D7C6-4BB6-A3DA-D0C331C19BC9Q27681060-96471256-CFDC-4BB2-A39E-D5C0F517C451Q27921848-7DD432CE-F555-45F2-8881-4BF8D7F78E1AQ28075814-94C88F61-C613-4217-A679-BDDEF0E79747Q28085561-8FFE9879-897B-418A-9B96-01AF52F6DFB6Q28118714-D24E57E8-DF2F-4903-BC50-298CC47CB8F7Q28254462-95CBD8ED-1D6C-4975-A3A2-08850628A0F9Q28277430-578E36C1-A134-4636-B266-9C8CD8B00E6EQ28383171-B45E753C-E045-484E-AD8C-229CF81DCA4BQ28384232-D47C5CB6-C680-4833-9AC9-A739FFF82C6AQ28384526-C63548F6-E82D-4234-9B76-F51A30EDCE0EQ28384783-466E36E9-FEF4-41F6-B647-F243AB66DA66Q28384997-5BF9A44D-3DCF-4064-9206-174E71FFB1CAQ28385517-2DC36F2C-A481-451E-A985-306442D5FF7EQ28386244-C8655584-3FAA-4BC9-80C3-C68D06BD0ECDQ28386384-863750E8-9A1D-43F3-9FA7-C4E966CB10F6Q28389296-2574D821-26B5-4794-ADBA-A8B0AF939467Q28391506-52DD68CD-BAFE-403D-A522-C602999EC3E1Q28392820-F061195A-F087-474E-9035-0AF0EA9EAD2CQ28394732-0CC6B4B9-111E-430A-B7F6-FC27D4D4F5D8Q28396785-9C53EE57-2C4E-4DDF-BED3-B0943CEB4A6AQ28482975-8AF4794B-0D50-49B6-A6A4-7C2753A68508Q28545231-B2004773-1794-4431-A0EE-85DE10D047FBQ28579883-EE56B77D-1721-4EB7-8354-865C794C2022Q28817936-EE4D9625-779A-4133-9BA7-418AFEBB791AQ28821830-79F0C410-2ED5-4DED-915B-D9C213F50296Q30371642-96013D19-4084-4D8F-ADD9-97B949F38CE3
P2860
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Dimerization of substrate adap ...... el for the Nrf2-Keap1 complex.
@en
Dimerization of substrate adap ...... el for the Nrf2-Keap1 complex.
@nl
type
label
Dimerization of substrate adap ...... el for the Nrf2-Keap1 complex.
@en
Dimerization of substrate adap ...... el for the Nrf2-Keap1 complex.
@nl
prefLabel
Dimerization of substrate adap ...... el for the Nrf2-Keap1 complex.
@en
Dimerization of substrate adap ...... el for the Nrf2-Keap1 complex.
@nl
P2093
P2860
P356
P1476
Dimerization of substrate adap ...... el for the Nrf2-Keap1 complex.
@en
P2093
Masayuki Yamamoto
Nerys Thomas
P2860
P304
24756-24768
P356
10.1074/JBC.M601119200
P407
P577
2006-06-21T00:00:00Z