A stapled p53 helix overcomes HDMX-mediated suppression of p53. - Wikidata - wikimedia - TriplyDB

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

http://www.wikidata.org/entity/Q39632109

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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization Inhibition of oncogenic Wnt signaling through direct targeting of -catenin In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy An Ultrahigh Affinity d -Peptide Antagonist Of MDM2 Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor Motif mediated protein-protein interactions as drug targets A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53 Hydrocarbon-stapled peptides: principles, practice, and progress Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting Constraining cyclic peptides to mimic protein structure motifs.Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1 A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia.MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition.Tissue-specific and age-dependent effects of global Mdm2 loss MDM2, MDMX and p53 in oncogenesis and cancer therapy Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.P53 mdm2 inhibitors.Translational synthetic chemistry.Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.Direct comparison of linear and macrocyclic compound libraries as a source of protein ligands Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions.Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles XI-006 induces potent p53-independent apoptosis in Ewing sarcoma.Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Improving matrix metalloproteinase-2 specific response of a hydrogel system using electrophoresis.Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides.High levels of Hdmx promote cell growth in a subset of uveal melanomas.Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia A New Methodology for Incorporating Chiral Linkers into Stapled Peptides.Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides

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P2860

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

http://www.wikidata.org/entity/Q39632109

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

@yue

2010年論文

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2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

@en

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

@nl

type

label

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

@en

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

@nl

prefLabel

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

@en

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

@nl

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J.CCR.2010.10.024

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A stapled p53 helix overcomes HDMX-mediated suppression of p53.

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David G Whitehead

http://www.w3.org/2001/XMLSchema#string

Federico Bernal

http://www.w3.org/2001/XMLSchema#string

Geoffrey M Wahl

http://www.w3.org/2001/XMLSchema#string

Loren D Walensky

http://www.w3.org/2001/XMLSchema#string

Marina Godes

http://www.w3.org/2001/XMLSchema#string

Mark Wade

http://www.w3.org/2001/XMLSchema#string

Tina N Davis

http://www.w3.org/2001/XMLSchema#string

P2860

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

A stapled BID BH3 helix directly binds and activates BAX

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

MDMX: a novel p53-binding protein with some functional properties of MDM2

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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