Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA.
about
DNA mismatch repair: molecular mechanism, cancer, and ageingSingle-molecule views of MutS on mismatched DNA.Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutSLarge conformational changes in MutS during DNA scanning, mismatch recognition and repair signalling.Mechanism of MutS searching for DNA mismatches and signaling repairMechanism of cadmium-mediated inhibition of Msh2-Msh6 function in DNA mismatch repairEvolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein.Saccharomyces cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair.The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome.Dynamical allosterism in the mechanism of action of DNA mismatch repair protein MutS.Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS.Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6Deciphering the mismatch recognition cycle in MutS and MSH2-MSH6 using normal-mode analysis.Mutations in the nucleotide binding and hydrolysis domains of Helicobacter pylori MutS2 lead to altered biochemical activities and inactivation of its in vivo function.MutL traps MutS at a DNA mismatch.Long-Range Signaling in MutS and MSH Homologs via Switching of Dynamic Communication PathwaysMismatch repairContribution of Msh2 and Msh6 subunits to the asymmetric ATPase and DNA mismatch binding activities of Saccharomyces cerevisiae Msh2-Msh6 mismatch repair protein.The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering.Roles for mismatch repair family proteins in promoting meiotic crossing over.Structure and mechanism for DNA lesion recognition.Modern aspects of the structural and functional organization of the DNA mismatch repair system.Mismatch binding, ADP-ATP exchange and intramolecular signaling during mismatch repair.Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.Application of stopped-flow kinetics methods to investigate the mechanism of action of a DNA repair protein.Single-Molecule FRET to Measure Conformational Dynamics of DNA Mismatch Repair Proteins.ATP binding and hydrolysis by Saccharomyces cerevisiae Msh2-Msh3 are differentially modulated by mismatch and double-strand break repair DNA substrates.The effects of nucleotides on MutS-DNA binding kinetics clarify the role of MutS ATPase activity in mismatch repair.Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNAMutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.The role of nucleotide cofactor binding in cooperativity and specificity of MutS recognition.The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death responseSlow conformational changes in MutS and DNA direct ordered transitions between mismatch search, recognition and signaling of DNA repair.Dependence of prevalence of contiguous pathways in proteins on structural complexity.MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner.Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS
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P2860
Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
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2004年论文
@zh-cn
name
Asymmetric ATP binding and hyd ...... eractions with mismatched DNA.
@en
Asymmetric ATP binding and hyd ...... eractions with mismatched DNA.
@nl
type
label
Asymmetric ATP binding and hyd ...... eractions with mismatched DNA.
@en
Asymmetric ATP binding and hyd ...... eractions with mismatched DNA.
@nl
prefLabel
Asymmetric ATP binding and hyd ...... eractions with mismatched DNA.
@en
Asymmetric ATP binding and hyd ...... eractions with mismatched DNA.
@nl
P2860
P356
P1433
P1476
Asymmetric ATP binding and hyd ...... eractions with mismatched DNA.
@en
P2093
Edwin Antony
Manju M Hingorani
P2860
P304
13115-13128
P356
10.1021/BI049010T
P407
P577
2004-10-01T00:00:00Z