Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q39686268

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Evaluation of traditional medicines for neurodegenerative diseases using Drosophila models Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice NF-kappa B modulation is involved in celastrol induced human multiple myeloma cell apoptosis Effects of Huanglian-Jie-Du-Tang and its modified formula on the modulation of amyloid-β precursor protein processing in Alzheimer's disease models The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer's Disease.Alzheimer's disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.Celastrol attenuates inflammatory and neuropathic pain mediated by cannabinoid receptor type 2.Hsp70 and its molecular role in nervous system diseases Targeting NOX enzymes in the central nervous system: therapeutic opportunities.Heat shock protein 90 in Alzheimer's disease The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation.Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.Molecular chaperones in Parkinson's disease--present and future Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology.Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells.A novel approach to recovery of function of mutant proteins by slowing down translation.BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer's disease.The central role of heat shock factor 1 in synaptic fidelity and memory consolidation The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity.Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP/PS1 transgenic mouse model.Knock-down of protein L-isoaspartyl O-methyltransferase increases β-amyloid production by decreasing ADAM10 and ADAM17 levels Protein Quality Control by Molecular Chaperones in Neurodegeneration.Association of heat-shock proteins in various neurodegenerative disorders: is it a master key to open the therapeutic door?Barcoding heat shock proteins to human diseases: looking beyond the heat shock response Molecular chaperones and neuronal proteostasis.Inhibition of IKKβ by celastrol and its analogues - an in silico and in vitro approach.Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol.The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained.Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease.Celastrol from 'Thunder God Vine' protects SH-SY5Y cells through the preservation of mitochondrial function and inhibition of p38 MAPK in a rotenone model of Parkinson's disease.Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.Localization of heat shock proteins in cerebral cortical cultures following induction by celastrol Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism.

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Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

http://www.wikidata.org/entity/Q39686268

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Reduction of beta-amyloid path ...... model of Alzheimer's disease.

@en

Reduction of beta-amyloid path ...... model of Alzheimer's disease.

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type

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Reduction of beta-amyloid path ...... model of Alzheimer's disease.

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Reduction of beta-amyloid path ...... model of Alzheimer's disease.

@nl

prefLabel

Reduction of beta-amyloid path ...... model of Alzheimer's disease.

@en

Reduction of beta-amyloid path ...... model of Alzheimer's disease.

@nl

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Journal of Neuroinflammation

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Reduction of beta-amyloid path ...... model of Alzheimer's disease.

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P2093

Amelia March

http://www.w3.org/2001/XMLSchema#string

Corbin Bachmeier

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Daniel Paris

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David Beaulieu-Abdelahad

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Nowell J Ganey

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Vincent Laporte

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease.

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.

Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.

Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease.

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scholarly article

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10.1186/1742-2094-7-17

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7

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Nikunj S. Patel

Ghania Ait-Ghezala

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2010-03-08T00:00:00Z

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41824399

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1026746873

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20211007

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Alzheimer's disease

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2841120

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