Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.
about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinLRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's diseaseFocal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice.The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related GenesBACE1 expression and activity: relevance in Alzheimer's diseaseBeta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque developmentPicomolar amyloid-β peptides enhance spontaneous astrocyte calcium transientsAltered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brainsΒ-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE).Beta-secretase activity increases with aging in human, monkey, and mouse brain.Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic miceAdaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.The Alzheimer's disease beta-secretase enzyme, BACE1.BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's diseaseLoss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.miR-186 is decreased in aged brain and suppresses BACE1 expressionBACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.PATHOBIOLOGY OF NEURODEGENERATION: THE ROLE FOR ASTROGLIA.The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptorsThe comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART eraInteractions between APP secretases and inflammatory mediators.Translational regulation of BACE-1 expression in neuronal and non-neuronal cells.Astrocytes in Alzheimer's disease.The miRNA pathway in neurological and skeletal muscle disease: implications for pathogenesis and therapy.Involvement of inflammation in Alzheimer's disease pathogenesis and therapeutic potential of anti-inflammatory agents.Astrocytes and synaptic plasticity in health and disease.Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytesTargeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease.Cloning and expression of the rat BACE1 promoter.β-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression.Beta-secretase-cleaved amyloid precursor protein in Alzheimer brain: a morphologic study.The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid β toxicity via its impaired cholesterol efflux.High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.Diversity of astroglial responses across human neurodegenerative disorders and brain aging.Neuronal and nonneuronal quantitative BACE immunocytochemical expression in the entorhinohippocampal and frontal regions in Alzheimer's disease.
P2860
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P2860
Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Neuronal and glial beta-secret ...... with amyloid plaque pathology.
@ast
Neuronal and glial beta-secret ...... with amyloid plaque pathology.
@en
type
label
Neuronal and glial beta-secret ...... with amyloid plaque pathology.
@ast
Neuronal and glial beta-secret ...... with amyloid plaque pathology.
@en
prefLabel
Neuronal and glial beta-secret ...... with amyloid plaque pathology.
@ast
Neuronal and glial beta-secret ...... with amyloid plaque pathology.
@en
P2093
P2860
P356
P1476
Neuronal and glial beta-secret ...... with amyloid plaque pathology.
@en
P2093
P2860
P304
P356
10.1002/JNR.1095
P577
2001-06-01T00:00:00Z