Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
about
The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related GenesDevelopment and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's diseaseFunction, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease.Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease.γ-Secretase directly sheds the survival receptor BCMA from plasma cellsSecretome protein enrichment identifies physiological BACE1 protease substrates in neuronsDifferential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodiesSeizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.Membrane trafficking pathways in Alzheimer's disease.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondThe changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseasesAmiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process.Antiviral activity of cationic amphiphilic drugs.Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines.Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats
P2860
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P2860
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Bepridil and amiodarone simult ...... etase via distinct mechanisms.
@en
Bepridil and amiodarone simult ...... etase via distinct mechanisms.
@nl
type
label
Bepridil and amiodarone simult ...... etase via distinct mechanisms.
@en
Bepridil and amiodarone simult ...... etase via distinct mechanisms.
@nl
prefLabel
Bepridil and amiodarone simult ...... etase via distinct mechanisms.
@en
Bepridil and amiodarone simult ...... etase via distinct mechanisms.
@nl
P2093
P1476
Bepridil and amiodarone simult ...... retase via distinct mechanisms
@en
P2093
Christian Haass
Deborah J Nelson
Edith Winkler
Frits Kamp
Harald Steiner
Huy-Riem Ha
Jessika Hopson
Jochen Herms
Richard M Page
Runa Hamid
P304
P356
10.1523/JNEUROSCI.1199-10.2010
P407
P577
2010-06-01T00:00:00Z