about
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 productionMT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.Proteomic Substrate Identification for Membrane Proteases in the BrainComputational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodiesSeizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitroSirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer's Disease Mouse Models.Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein.GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.gamma-Secretase cleavage site specificity differs for intracellular and secretory amyloid beta.Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion.Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.Non-cell-autonomous function of DR6 in Schwann cell proliferation.The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation.An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments.Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation.Prion replication in the mammalian cytosol: Functional regions within a prion domain driving induction, propagation and inheritance.Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptorCADASIL brain vessels show a HTRA1 loss-of-function profileSignal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteinsNrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's diseaseCell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's DiseaseMutations in the transmembrane domain of APP altering gamma-secretase specificityA novel substrate for analyzing Alzheimer's disease gamma-secretaseLarge-scale screens for cDNAs with in vivo activityCell biology. Sheddase gets guidanceProteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developmentsBACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brainsSignal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteinsCell-type-specific profiling of brain mitochondria reveals functional and molecular diversityDiscovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
Stefan F Lichtenthaler
@en
Stefan F Lichtenthaler
@nl
type
label
Stefan F Lichtenthaler
@en
Stefan F Lichtenthaler
@nl
prefLabel
Stefan F Lichtenthaler
@en
Stefan F Lichtenthaler
@nl
P106
P31
P496
0000-0003-2211-2575