Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides. - Wikidata - wikimedia - TriplyDB

Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.

Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.

http://www.wikidata.org/entity/Q39725736

about

Targeting Toll-like receptors with small molecule agents Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen.Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds.Structure-activity relationships in human Toll-like receptor 8-active 2,3-diamino-furo[2,3-c]pyridines.A TLR2 agonist is a more effective adjuvant for a Chlamydia major outer membrane protein vaccine than ligands to other TLR and NOD receptors.Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide.Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants.TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.Self-adjuvanting lipoimmunogens for therapeutic HPV vaccine development: potential clinical impact.Strategies for designing synthetic immune agonists.Controlling the origins of inflammation with a photoactive lipopeptide immunopotentiator.Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides.Potent adjuvantic activity of a CCR1-agonistic bis-quinoline.Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines.Light Guided In-vivo Activation of Innate Immune Cells with Photocaged TLR 2/6 Agonist.Toward self-adjuvanting subunit vaccines: model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines.Structure-activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides.Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines.Structure-activity relationships in nucleotide oligomerization domain 1 (Nod1) agonistic γ-glutamyldiaminopimelic acid derivatives.Peptide Lipidation - A Synthetic Strategy to Afford Peptide Based Therapeutics.Glycerol as Precursor of Organoselanyl and Organotellanyl Alkynes.Syntheses of Human TLR8-Specific Small-Molecule Agonists.

P2860

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P2860

Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.

http://www.wikidata.org/entity/Q39725736

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Structure-activity relationshi ...... acylthioglycerol lipopeptides.

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Structure-activity relationshi ...... acylthioglycerol lipopeptides.

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type

label

Structure-activity relationshi ...... acylthioglycerol lipopeptides.

@en

Structure-activity relationshi ...... acylthioglycerol lipopeptides.

@nl

prefLabel

Structure-activity relationshi ...... acylthioglycerol lipopeptides.

@en

Structure-activity relationshi ...... acylthioglycerol lipopeptides.

@nl

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Journal of Medicinal Chemistry

P1476

Structure-activity relationshi ...... acylthioglycerol lipopeptides.

@en

P2093

Apurba Datta

http://www.w3.org/2001/XMLSchema#string

Hemamali J Warshakoon

http://www.w3.org/2001/XMLSchema#string

Matthew R Kimbrell

http://www.w3.org/2001/XMLSchema#string

Michael W Amolins

http://www.w3.org/2001/XMLSchema#string

Rehman Ukani

http://www.w3.org/2001/XMLSchema#string

Rongti Li

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Subbalakshmi S Malladi

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Sunil A David

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Wenyan Wu

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P2860

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

Pathogen recognition and innate immunity

Infection and cancer

Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling

Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2

Lipopeptide structure determines TLR2 dependent cell activation level.

A 48-kilodalton Mycoplasma fermentans membrane protein induces cytokine secretion by human monocytes

TLR2: cellular sensor for microbial and endogenous molecular patterns.

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3198-3213

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10.1021/JM901839G

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8

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20302301

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Toll-like receptor

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2859677

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