The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity.
about
Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTRA human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongationIt all comes together at the ends: telomerase structure, function, and biogenesisMolecular regulation of telomerase activity in agingStructurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNAAn anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalizationRegulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domainHuman telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivoInsights into the evolution of mammalian telomerase: platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomesIdentification of human TERT elements necessary for telomerase recruitment to telomeres.Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy.The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegansThe telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomeraseThe protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa.The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalizationA novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.A physical and functional constituent of telomerase anchor site.Ribonucleoprotein multimers and their functions.InTERTpreting telomerase structure and functionGenetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies.Direct involvement of the TEN domain at the active site of human telomeraseDyskeratosis congenita as a disorder of telomere maintenance.RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency.Cloning and molecular characterization of telomerase reverse transcriptase (TERT) and telomere length analysis of Peromyscus leucopus.Characterization of physical and functional anchor site interactions in human telomerase.HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human HepatocytesCoupling a DNA-Based Machine with Glucometer Readouts for Amplified Detection of Telomerase Activity in Cancer Cells.A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome.Yeast telomerase is capable of limited repeat addition processivityFundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells.Telomere lengthening and other functions of telomerase.Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme.Multiple DNA-binding sites in Tetrahymena telomerase.An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance.Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532A single quantum dot-based biosensor for telomerase assay.Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes.Human telomerase catalyzes nucleolytic primer cleavage.
P2860
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P2860
The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The C terminus of the human te ...... minant of enzyme processivity.
@en
The C terminus of the human te ...... minant of enzyme processivity.
@nl
type
label
The C terminus of the human te ...... minant of enzyme processivity.
@en
The C terminus of the human te ...... minant of enzyme processivity.
@nl
prefLabel
The C terminus of the human te ...... minant of enzyme processivity.
@en
The C terminus of the human te ...... minant of enzyme processivity.
@nl
P2860
P356
P1476
The C terminus of the human te ...... minant of enzyme processivity.
@en
P2093
Sylvain Huard
Tara J Moriarty
P2860
P304
P356
10.1093/NAR/GKG437
P407
P577
2003-07-01T00:00:00Z