A novel pathway for amyloid precursor protein processing.
about
The potential of pathological protein fragmentation in blood-based biomarker development for dementia - with emphasis on Alzheimer's diseaseA window into the heterogeneity of human cerebrospinal fluid Aβ peptidesAmyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation.BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous systemUpdate on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease.Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease.Alzheimer's Disease Cerebrospinal Fluid and Neuroimaging Biomarkers: Diagnostic Accuracy and Relationship to Drug Efficacy.Amyloid-β metabolism in Niemann-Pick C disease models and patients.Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease.YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice.CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer diseaseA novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer diseaseAcute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta reboundEvaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: from the cell to the patient.The amyloid-β isoform pattern in cerebrospinal fluid in familial PSEN1 M139T- and L286P-associated Alzheimer's diseaseNew highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer's diseasePeptidome analysis of cerebrospinal fluid by LC-MALDI MSRegulation of presynaptic Ca2+, synaptic plasticity and contextual fear conditioning by a N-terminal β-amyloid fragment.Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions.Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization.Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional studyHeteromers of amyloid precursor protein in cerebrospinal fluid.Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluidThe "Alzheimer's disease signature": potential perspectives for novel biomarkers.Alzheimer's Disease: Lessons Learned from Amyloidocentric Clinical Trials.Intracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic Mice.Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stagesSpecific Triazine Herbicides Induce Amyloid-β42 Production.Fluid biomarkers in Alzheimer disease.Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease.CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease.A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans.Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme.Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus.Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity.Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease.Cerebrospinal fluid analysis in Alzheimer's disease: technical issues and future developments.Truncated and modified amyloid-beta species.Transmembrane Amyloid-Related Proteins in CSF as Potential Biomarkers for Alzheimer's Disease.
P2860
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P2860
A novel pathway for amyloid precursor protein processing.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
A novel pathway for amyloid precursor protein processing.
@en
A novel pathway for amyloid precursor protein processing.
@nl
type
label
A novel pathway for amyloid precursor protein processing.
@en
A novel pathway for amyloid precursor protein processing.
@nl
prefLabel
A novel pathway for amyloid precursor protein processing.
@en
A novel pathway for amyloid precursor protein processing.
@nl
P2093
P50
P1476
A novel pathway for amyloid precursor protein processing.
@en
P2093
Adam J Simon
Eric Price
Maria Olsson
Mark Stiteler
Rita Persson
P304
P356
10.1016/J.NEUROBIOLAGING.2009.06.002
P577
2009-07-14T00:00:00Z