about
The multiple connections between pRB and cell metabolismTwo-way communication between the metabolic and cell cycle machineries: the molecular basisThe cell cycle as a brake for β-cell regeneration from embryonic stem cellsEmerging links between E2F control and mitochondrial functionCDK4 is an essential insulin effector in adipocytesBone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis developmentIslet biology, the CDKN2A/B locus and type 2 diabetes risk.The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype.Ectopic expression of E2F1 stimulates beta-cell proliferation and function.Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells.Metabolism and proliferation share common regulatory pathways in cancer cells.PPARβ Regulates Liver Regeneration by Modulating Akt and E2f Signaling.The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretionCycling through metabolism.PPARγ contributes to PKM2 and HK2 expression in fatty liverThe sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissuesEvidence for autoregulation and cell signaling pathway regulation from genome-wide binding of the Drosophila retinoblastoma protein.E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafishRB1, development, and cancer.Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.E2F transcription factor-1 regulates oxidative metabolism.Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC.Gestational diabetes leads to down-regulation of CDK4-pRB-E2F1 pathway genes in pancreatic islets of rat offspring.Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions.Diabetes mellitus--advances and challenges in human β-cell proliferation.Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action.p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein.CDK4, pRB and E2F1: connected to insulin.Cyclin G2 regulates adipogenesis through PPAR gamma coactivation.Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.Liver histone H3 methylation and acetylation may associate with type 2 diabetes development.Overexpression of E2F3 promotes proliferation of functional human β cells without induction of apoptosis.Cell cycle regulators in the control of metabolism.Re-thinking cell cycle regulators: the cross-talk with metabolism.Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging.E2F1, a Novel Regulator of Metabolism.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
The CDK4-pRB-E2F1 pathway controls insulin secretion.
@en
The CDK4-pRB-E2F1 pathway controls insulin secretion.
@nl
type
label
The CDK4-pRB-E2F1 pathway controls insulin secretion.
@en
The CDK4-pRB-E2F1 pathway controls insulin secretion.
@nl
prefLabel
The CDK4-pRB-E2F1 pathway controls insulin secretion.
@en
The CDK4-pRB-E2F1 pathway controls insulin secretion.
@nl
P2093
P2860
P356
P1433
P1476
The CDK4-pRB-E2F1 pathway controls insulin secretion.
@en
P2093
Carine Chavey
Claude Sardet
Emilie Blanchet
Irena Iankova
Jacques Teyssier
Lluis Fajas
Safia Costes
Said Assou
Stéphane Dalle
P2860
P2888
P304
P356
10.1038/NCB1915
P577
2009-07-13T00:00:00Z