PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
about
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repairMRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaksBreast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksBreast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repairDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsThe Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondiiRole of Deubiquitinating Enzymes in DNA RepairTherapeutic Implications for Overcoming Radiation Resistance in Cancer TherapyThe Fanconi anemia pathway and DNA interstrand cross-link repairHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesMitotic homologous recombination maintains genomic stability and suppresses tumorigenesisRAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombinationCooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombinationLoss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppressionExpanded roles of the Fanconi anemia pathway in preserving genomic stabilityRare germline mutations in PALB2 and breast cancer risk: a population-based study.Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motifFunctional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistanceA fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.An entire exon 3 germ-line rearrangement in the BRCA2 gene: pathogenic relevance of exon 3 deletion in breast cancer predispositionMale fertility defect associated with disrupted BRCA1-PALB2 interaction in micePALB2/FANCN: recombining cancer and Fanconi anemia.Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement.BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.Functional and structural analysis of C-terminal BRCA1 missense variants.The role of BRCA1 in DNA damage response.Evaluation of the need for routine clinical testing of PALB2 c.1592delT mutation in BRCA negative Northern Finnish breast cancer familiesSynthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American populationDNA repair mechanisms in cancer development and therapyβ-HPV 5 and 8 E6 disrupt homology dependent double strand break repair by attenuating BRCA1 and BRCA2 expression and foci formation.Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673.BRCA1 tumor suppressor network: focusing on its tail.PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and functionA Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour DevelopmentBRCA1 Mutation: A Predictive Marker for Radiation Therapy?
P2860
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P2860
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
@en
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
@nl
type
label
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
@en
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
@nl
prefLabel
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
@en
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
@nl
P2093
P2860
P1476
PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
@en
P2093
Paul R Andreassen
P2860
P304
P356
10.1158/1541-7786.MCR-09-0123
P577
2009-07-07T00:00:00Z