The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage
about
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerThe cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial designThe intersection between DNA damage response and cell death pathwaysRare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancerDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMFanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction.NF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexesThe Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cellsCHK2 kinase in the DNA damage response and beyondSensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo.The fork and the kinase: a DNA replication tale from a CHK1 perspective.Activation of checkpoint kinase 2 is critical for herpes simplex virus type 1 replication in corneal epitheliumEnhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition.mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibitionLAMMER kinase contributes to genome stability in Ustilago maydis.Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.Sensitization of tumor to ²¹²Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51.High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.Replicating damaged DNA in eukaryotes.Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.Selective tumor killing based on specific DNA-damage response deficiencies.Replication fork dynamics and the DNA damage response.Cellular-signaling pathways unveil the carcinogenic potential of chemicals.Checkpoint kinase 1 negatively regulates somatic hypermutation.Therapeutic potential of investigational CHK-1 inhibitors for the treatment of solid tumors.CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute.PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation.NF-κB-dependent DNA damage-signaling differentially regulates DNA double-strand break repair mechanisms in immature and mature human hematopoietic cells.A fragmented alignment method detects a putative phosphorylation site and a putative BRC repeat in the Drosophila melanogaster BRCA2 protein.MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis.Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.Checkpoint kinase 2 is required for efficient immunoglobulin diversification.Suppression of the FA pathway combined with CHK1 inhibitor hypersensitize lung cancer cells to gemcitabine.
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P2860
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage
description
2008 nî lūn-bûn
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2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2008 թվականի հունիսին հրատարակված գիտական հոդված
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年學術文章
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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The checkpoint kinases Chk1 an ...... ad51 in response to DNA damage
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A L Riesenberg
E M Bahassi
J L Ovesen
P J Stambrook
W Z Bernstein
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10.1038/ONC.2008.17
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2008-06-26T00:00:00Z
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1016793468