about
Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signalingDifferent effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cellsThe novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor proteinParkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stressThe E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMOIntracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion diseaseThe Cellular Prion Protein: A Player in Immunological QuiescenceParkin is protective against proteotoxic stress in a transgenic zebrafish modelAnti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulationsThe N-terminus of the prion protein is a toxic effector regulated by the C-terminus.A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.Folding and misfolding of the prion protein in the secretory pathway.Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degenerationThe role of chaperones in Parkinson's disease and prion diseases.Propagation of prion strains through specific conformers of the prion proteinMolecular basis of cerebral neurodegeneration in prion diseases.The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases.Neuroprotective and neurotoxic signaling by the prion protein.Prion disease: a tale of folds and strains.The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum.Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria.Conserved stress-protective activity between prion protein and ShadooConditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulumLoss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentationGreen tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.Stress-protective signalling of prion protein is corrupted by scrapie prions.The mechanism of adenovirus DNA integration: studies in a cell-free system.Pathogenic mutations inactivate parkin by distinct mechanisms.Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation.Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones.Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice.Geldanamycin restores a defective heat shock response in vivo.The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor.Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Jorg Tatzelt
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Jorg Tatzelt
@en
Jorg Tatzelt
@es
Jorg Tatzelt
@nl
Jorg Tatzelt
@sl
type
label
Jorg Tatzelt
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Jorg Tatzelt
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Jorg Tatzelt
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Jorg Tatzelt
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Jorg Tatzelt
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J Tatzelt
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Jörg Tatzelt
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Jorg Tatzelt
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Jorg Tatzelt
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Jorg Tatzelt
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Jorg Tatzelt
@nl
Jorg Tatzelt
@sl
P106
P21
P2798
P31
P496
0000-0001-5017-5528