Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
about
Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenaseKinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyXResistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitnessHost reticulocytes provide metabolic reservoirs that can be exploited by malaria parasitesTargeting purine and pyrimidine metabolism in human apicomplexan parasitesImpact of schistosome infection on Plasmodium falciparum Malariometric indices and immune correlates in school age children in Burma Valley, Zimbabwe.Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum.Leaving group activation and pyrophosphate ionic state at the catalytic site of Plasmodium falciparum orotate phosphoribosyltransferase.Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694UDP-galactose 4'-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors.Antimalarial activity of a combination of 5-fluoroorotate and uridine in miceIn vitro susceptibilities of Plasmodium falciparum to compounds which inhibit nucleotide metabolismStructure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions.Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate.Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum.Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum.Purine and pyrimidine pathways as targets in Plasmodium falciparum.Variations in frequencies of drug resistance in Plasmodium falciparum.Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferasesChemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.
P2860
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P2860
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
@en
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
@nl
type
label
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
@en
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
@nl
prefLabel
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
@en
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
@nl
P2093
P2860
P356
P1476
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
@en
P2093
P2860
P304
P356
10.1128/AAC.33.7.1090
P407
P577
1989-07-01T00:00:00Z