Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins.
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Respiratory distress and perinatal lethality in Nedd4-2-deficient micePermeation, selectivity and gating in store-operated CRAC channelsOrai3--the 'exceptional' Orai?The STIM1/Orai signaling machineryStore-operated Orai channels: structure and functionNon-stimulated, agonist-stimulated and store-operated Ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entryActivating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis.STIM and Orai isoform expression in pregnant human myometrium: a potential role in calcium signaling during pregnancy.The boron-oxygen core of borinate esters is responsible for the store-operated calcium entry potentiation ability.Sequential Steps of CRAC Channel Activation.CRAC channelopathies.Steatosis inhibits liver cell store-operated Ca²⁺ entry and reduces ER Ca²⁺ through a protein kinase C-dependent mechanism.Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.Molecular biophysics of Orai store-operated Ca2+ channels.Epstein-Barr virus latent membrane protein 1 increases calcium influx through store-operated channels in B lymphoid cells.Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).STIM1L traps and gates Orai1 channels without remodeling the cortical ERStore-operated calcium channels: new perspectives on mechanism and function.Store-operated calcium entry: Mechanisms and modulation.Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx.Orai1 pore residues control CRAC channel inactivation independently of calmodulin.The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation.Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101Thiol dependent intramolecular locking of Orai1 channels.A TRPC1 protein-dependent pathway regulates osteoclast formation and function.Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channelsSTIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels.A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.Orai1-NFAT signalling pathway triggered by T cell receptor stimulation.An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs.Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.Electrophysiological Features of Single Store-Operated Calcium Channels in HEK S4 Cell Line with Stable STIM1 Protein Knockdown.Molecular mechanisms of STIM/Orai communication.Changing calcium: CRAC channel (STIM and Orai) expression, splicing, and posttranslational modifiers.The STIM-Orai coupling interface and gating of the Orai1 channel.Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry.Gated regulation of CRAC channel ion selectivity by STIM1.STIM1 dimers undergo unimolecular coupling to activate Orai1 channels.
P2860
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P2860
Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Properties of Orai1 mediated s ...... s of STIM1 and Orai1 proteins.
@en
Properties of Orai1 mediated s ...... s of STIM1 and Orai1 proteins.
@nl
type
label
Properties of Orai1 mediated s ...... s of STIM1 and Orai1 proteins.
@en
Properties of Orai1 mediated s ...... s of STIM1 and Orai1 proteins.
@nl
prefLabel
Properties of Orai1 mediated s ...... s of STIM1 and Orai1 proteins.
@en
Properties of Orai1 mediated s ...... s of STIM1 and Orai1 proteins.
@nl
P2093
P2860
P1476
Properties of Orai1 mediated s ...... s of STIM1 and Orai1 proteins.
@en
P2093
P2860
P304
P356
10.1113/JPHYSIOL.2009.170662
P407
P577
2009-04-29T00:00:00Z