Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. - Wikidata - wikimedia - TriplyDB

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

http://www.wikidata.org/entity/Q39867658

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Rap2A links intestinal cell polarity to brush border formation PLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes The multiple faces of leukocyte interstitial migration Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse Visualization of phosphatidic acid fluctuations in the plasma membrane of living cells Structural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.The phospholipase D superfamily as therapeutic targets Role of mitochondrial lipids in guiding fission and fusion Exploiting publicly available biological and biochemical information for the discovery of novel short linear motifs Random versus directionally persistent cell migration Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development.Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction A phosphatidic acid binding/nuclear localization motif determines lipin1 function in lipid metabolism and adipogenesis Two-photon microscopy analysis of leukocyte trafficking and motility.Migrating human neutrophils exhibit dynamic spatiotemporal variation in membrane lipid organization.Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.Asymmetric PI(3,4,5)P3 and Akt signaling mediates chemotaxis of axonal growth cones.The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient.DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device.Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.Cellular and physiological roles for phospholipase D1 in cancer.Cellular responses to extracellular guidance cues Dedicator of cytokinesis 8 (DOCK8) deficiency Protein kinase Cdelta-mediated phosphorylation of phospholipase D controls integrin-mediated cell spreading.cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensor Roles of ADF/cofilin in actin polymerization and beyond

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P2860

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

http://www.wikidata.org/entity/Q39867658

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

Sequential regulation of DOCK2 ...... during neutrophil chemotaxis.

@en

Sequential regulation of DOCK2 ...... during neutrophil chemotaxis.

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type

label

Sequential regulation of DOCK2 ...... during neutrophil chemotaxis.

@en

Sequential regulation of DOCK2 ...... during neutrophil chemotaxis.

@nl

prefLabel

Sequential regulation of DOCK2 ...... during neutrophil chemotaxis.

@en

Sequential regulation of DOCK2 ...... during neutrophil chemotaxis.

@nl

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SCIENCE.1170179

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Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis

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Fumiyuki Sanematsu

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Hideo Fukuhara

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Hiroshi Hasegawa

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Hisashi Mihara

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Masakatsu Shibasaki

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Michael A Frohman

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Motomu Kanai

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Qinhong Cao

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Shunsuke Takasuga

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Tsunaki Hongu

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P2860

Localized Rac activation dynamics visualized in living cells

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis

Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium

A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

Cell migration: integrating signals from front to back

Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid.

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity

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384-387

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5925

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324

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Akihiko Nishikimi

Yoshinori Fukui

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2009-03-26T00:00:00Z

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19325080

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3761877

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