Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
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3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cellsDirect inhibition of the NOTCH transcription factor complexAdult hematopoietic stem cells require NKAP for maintenance and survivalDiscovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.Controlling destiny through chemistry: small-molecule regulators of cell fate.The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathwaysGenome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer.Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemiaHijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic miceTargeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells.Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational studySystems approaches to polypharmacology and drug discoveryPhase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma.Notch Signaling in T-Cell Development and T-ALLSpecific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptorNeurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development.Emerging pharmacotherapies for adult patients with acute lymphoblastic leukemia.Defining NOTCH3 target genes in ovarian cancer.Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemiaIn vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models.The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.Prolonged inhibition of glioblastoma xenograft initiation and clonogenic growth following in vivo Notch blockadeNotch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transitionDown-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.The role of Notch and gamma-secretase inhibition in an ovarian cancer modelThe role of NOTCH1 signaling in T-ALL.Cell cycle-independent roles of p19INK4d in human terminal erythropoiesis.Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.Notch regulation of tumor angiogenesis.Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises.Recent developments in the management of T-cell precursor acute lymphoblastic leukemia/lymphoma.The emerging field of chemo- and pharmacoproteomics.Lessons from next-generation sequencing analysis in hematological malignancies.
P2860
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P2860
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Inhibition of NOTCH signaling ...... lymphoblastic leukemia cells.
@en
Inhibition of NOTCH signaling ...... lymphoblastic leukemia cells.
@nl
type
label
Inhibition of NOTCH signaling ...... lymphoblastic leukemia cells.
@en
Inhibition of NOTCH signaling ...... lymphoblastic leukemia cells.
@nl
prefLabel
Inhibition of NOTCH signaling ...... lymphoblastic leukemia cells.
@en
Inhibition of NOTCH signaling ...... lymphoblastic leukemia cells.
@nl
P2093
P1433
P1476
Inhibition of NOTCH signaling ...... e lymphoblastic leukemia cells
@en
P2093
A Thomas Look
Christopher G Winter
Cole D Liberator
Edyta Tyminski
Giulio F Draetta
James S Hardwick
Jennifer O'Neil
Lex H T Van der Ploeg
Nancy E Kohl
P304
P356
10.1158/0008-5472.CAN-08-4295
P407
P577
2009-03-24T00:00:00Z