The human cytomegalovirus IE2 86-kilodalton protein interacts with an early gene promoter via site-specific DNA binding and protein-protein associations.
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Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcriptionAutorepression of the human cytomegalovirus major immediate-early promoter/enhancer at late times of infection is mediated by the recruitment of chromatin remodeling enzymes by IE86Activation of transcription of the human cytomegalovirus early UL4 promoter by the Ets transcription factor binding element.Transcriptional regulation of the human cytomegalovirus US11 early gene.Effects of human cytomegalovirus major immediate-early proteins in controlling the cell cycle and inhibiting apoptosis: studies with ts13 cellsDefective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant.Identification of positive and negative regulatory regions involved in regulating expression of the human cytomegalovirus UL94 late promoter: role of IE2-86 and cellular p53 in mediating negative regulatory function.Phosphorylation of the human cytomegalovirus 86-kilodalton immediate-early protein IE2.Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b.The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells.Evaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9Effect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: a DNA microarray analysis.Role of noncovalent SUMO binding by the human cytomegalovirus IE2 transactivator in lytic growth.Functional properties of the human cytomegalovirus IE86 protein required for transcriptional regulation and virus replicationRole of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression.Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression.Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.Multiple regulatory events influence human cytomegalovirus DNA polymerase (UL54) expression during viral infectionTAF-like functions of human cytomegalovirus immediate-early proteinsThe host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication.Inhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator.Two Polypyrimidine Tracts in Intron 4 of the Major Immediate Early Gene Are Critical for Gene Expression Switching from IE1 to IE2 and for Replication of Human CytomegalovirusIdentification of cellular proteins that interact with human cytomegalovirus immediate-early protein 1 by protein array assay.Cytomegalovirus IE2 protein stimulates interleukin 1beta gene transcription via tethering to Spi-1/PU.1.H2B homology region of major immediate-early protein 1 is essential for murine cytomegalovirus to disrupt nuclear domain 10, but is not important for viral replication in cell culture.The human cytomegalovirus 86-kilodalton major immediate-early protein interacts physically and functionally with histone acetyltransferase P/CAF.Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes.Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replicationNovel immediate-early protein IE19 of human cytomegalovirus activates the origin recognition complex I promoter in a cooperative manner with IE72.Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.CREB and CREB-binding proteins play an important role in the IE2 86-kilodalton protein-mediated transactivation of the human cytomegalovirus 2.2-kilobase RNA promoter.Translational regulation of the human cytomegalovirus pp28 (UL99) late geneBinding of SP1 to the immediate-early protein-responsive element of the human cytomegalovirus DNA polymerase promoter.The UL84 protein of human cytomegalovirus acts as a transdominant inhibitor of immediate-early-mediated transactivation that is able to prevent viral replication.Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other.Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomesRecruitment of human cytomegalovirus immediate-early 2 protein onto parental viral genomes in association with ND10 in live-infected cells.
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P2860
The human cytomegalovirus IE2 86-kilodalton protein interacts with an early gene promoter via site-specific DNA binding and protein-protein associations.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
The human cytomegalovirus IE2 ...... protein-protein associations.
@en
The human cytomegalovirus IE2 ...... protein-protein associations.
@nl
type
label
The human cytomegalovirus IE2 ...... protein-protein associations.
@en
The human cytomegalovirus IE2 ...... protein-protein associations.
@nl
prefLabel
The human cytomegalovirus IE2 ...... protein-protein associations.
@en
The human cytomegalovirus IE2 ...... protein-protein associations.
@nl
P2093
P2860
P1433
P1476
The human cytomegalovirus IE2 ...... protein-protein associations.
@en
P2093
A L Scully
D H Spector
M H Sommer
R Schwartz
P2860
P304
P407
P577
1995-10-01T00:00:00Z