Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
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Inhibition of nutlin-resistant HDM2 mutants by stapled peptidesElucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulationsIn vitro selection of mutant HDM2 resistant to Nutlin inhibitionC-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanismsSimulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamicsProbing Difference in Binding Modes of Inhibitors to MDMX by Molecular Dynamics Simulations and Different Free Energy MethodsMDM2 and MDMX: Alone and together in regulation of p53Molecular basis of Bcl-X(L)-p53 interaction: insights from molecular dynamics simulations.Binding of Translationally Controlled Tumour Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3.Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach.Computational studies of difference in binding modes of peptide and non-peptide inhibitors to MDM2/MDMX based on molecular dynamics simulations.Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cellsHydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations.Molecular dynamic simulation insights into the normal state and restoration of p53 function.High levels of Hdmx promote cell growth in a subset of uveal melanomas.Probing Origin of Binding Difference of inhibitors to MDM2 and MDMX by Polarizable Molecular Dynamics Simulation and QM/MM-GBSA CalculationLigand binding mode prediction by docking: mdm2/mdmx inhibitors as a case studyOn the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.Structural Exploration and Conformational Transitions in MDM2 upon DHFR Interaction from Homo sapiens: A Computational Outlook for Malignancy via Epigenetic Disruption.Targeting ubiquitination for cancer therapies.On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein.The structure-based design of Mdm2/Mdmx-p53 inhibitors gets seriousRegulation of p53: a collaboration between Mdm2 and Mdmx.Targeting p53-MDM2-MDMX loop for cancer therapy.Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts.Regulation of transcriptional activators by DNA-binding domain ubiquitination.Peptides and peptidomimetics in the p53/MDM2/MDM4 circuitry - a patent review.Application of binding free energy calculations to prediction of binding modes and affinities of MDM2 and MDMX inhibitors.Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.Designing dual inhibitors of Mdm2/MdmX: Unexpected coupling of water with gatekeeper Y100/99.MDMX under stress: the MDMX-MDM2 complex as stress signals hub
P2860
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P2860
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
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2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
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2010年學術文章
@zh-hant
name
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
@en
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
@nl
type
label
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
@en
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
@nl
prefLabel
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
@en
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
@nl
P2093
P356
P1433
P1476
Differential binding of p53 and nutlin to MDM2 and MDMX: computational studies.
@en
P2093
Chandra S Verma
Christopher J Brown
David P Lane
Thomas Leonard Joseph
P304
P356
10.4161/CC.9.6.11067
P577
2010-03-15T00:00:00Z