RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress
about
Transcription Blockage Leads to New BeginningsThe role of RecQ helicases in non-homologous end-joiningReplication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stabilityGetting up to speed with transcription elongation by RNA polymerase IIDysregulation of gene expression as a cause of Cockayne syndrome neurological disease.Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice.Quantitative regulation of FLC via coordinated transcriptional initiation and elongationClinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells.RECQ helicases are deregulated in hematological malignancies in association with a prognostic valueReplication stress and cancer: it takes two to tango.The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongationRECQ5 helicase promotes resolution of conflicts between replication and transcription in human cellsHolliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase.Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.Mutation of cancer driver MLL2 results in transcription stress and genome instability.DNA replication stress: from molecular mechanisms to human disease.UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same GeneProtection or resection: BOD1L as a novel replication fork protection factor.Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation.CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes.The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.Transcription-replication conflicts at chromosomal fragile sites-consequences in M phase and beyond.Conflict Resolution in the Genome: How Transcription and Replication Make It Work.Replication Fork Protection Factors Controlling R-Loop Bypass and SuppressionHuman RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.Pause & go: from the discovery of RNA polymerase pausing to its functional implications.RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability.Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq.Expanding the SRI domain family: a common scaffold for binding the phosphorylated C-terminal domain of RNA polymerase II.Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.CDK9-dependent RNA polymerase II pausing controls transcription initiation.Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate.RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.Gene length as a biological timer to establish temporal transcriptional regulation.Global Run-On Sequencing (GRO-Seq).Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study.
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P2860
RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
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2014年學術文章
@zh-hant
name
RECQL5 controls transcript elo ...... ated with transcription stress
@en
RECQL5 controls transcript elo ...... ted with transcription stress.
@nl
type
label
RECQL5 controls transcript elo ...... ated with transcription stress
@en
RECQL5 controls transcript elo ...... ted with transcription stress.
@nl
prefLabel
RECQL5 controls transcript elo ...... ated with transcription stress
@en
RECQL5 controls transcript elo ...... ted with transcription stress.
@nl
P2860
P50
P1433
P1476
RECQL5 controls transcript elo ...... ated with transcription stress
@en
P2093
Mark Heron
P2860
P304
P356
10.1016/J.CELL.2014.03.048
P407
P50
P577
2014-05-15T00:00:00Z