Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea
about
The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesisNomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraeaSystems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains.Analysis of an 8.1-kb DNA fragment contiguous with the erythromycin gene cluster of Saccharopolyspora erythraea in the eryCI-flanking region.Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field.An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strainComparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain.Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase.Random transposon mutagenesis of the Saccharopolyspora erythraea genome reveals additional genes influencing erythromycin biosynthesis.Knockout of the erythromycin biosynthetic cluster gene, eryBI, blocks isoflavone glucoside bioconversion during erythromycin fermentations in Aeromicrobium erythreum but not in Saccharopolyspora erythraeaPurification, crystallization and preliminary X-ray analysis of NtdA, a putative pyridoxal phosphate-dependent aminotransferase from Bacillus subtilis.Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin productionEngineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin productionSACE_0012, a TetR-family transcriptional regulator, affects the morphogenesis of Saccharopolyspora erythraeaSACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology.Transcriptional organization of the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea.Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production.Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis.Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacementIn vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea.Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching.Engineering antibiotic producers to overcome the limitations of classical strain improvement programs.Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea.Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea.The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.Investigation of tailoring modifications in pradimicin biosynthesis.A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea.Engineering broader specificity into an antibiotic-producing polyketide synthase.Capturing the target genes of BldD in Saccharopolyspora erythraea using improved genomic SELEX method.SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea.
P2860
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P2860
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea
description
1990 nî lūn-bûn
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1990年の論文
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1990年学术文章
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1990年学术文章
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1990年学术文章
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1990年学术文章
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1990年学术文章
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1990年學術文章
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1990年學術文章
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name
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea
@en
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea.
@nl
type
label
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea
@en
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea.
@nl
prefLabel
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea
@en
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea.
@nl
P2093
P2860
P1476
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea
@en
P2093
P2860
P304
P356
10.1128/JB.172.5.2372-2383.1990
P577
1990-05-01T00:00:00Z