Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae.
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The bacterial ribosome as a target for antibioticsConjugation and transformation of Streptomyces species by tylosin resistance.The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA.Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria.Negative in vitro selection identifies the rRNA recognition motif for ErmE methyltransferaseResistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividans.The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production23S rRNA domain V, a fragment that can be specifically methylated in vitro by the ErmSF (TlrA) methyltransferase.Avoidance of suicide in antibiotic-producing microbes.The expression of antibiotic resistance genes in antibiotic-producing bacteria.A novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis.Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.Erythromycin resistance by ribosome modification.Role of an energy-dependent efflux pump in plasmid pNE24-mediated resistance to 14- and 15-membered macrolides in Staphylococcus epidermidis.Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''.Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferaseRole of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.Organization of a cluster of erythromycin genes in Saccharopolyspora erythraeaSite-specific methylation of 16S rRNA caused by pct, a pactamycin resistance determinant from the producing organism, Streptomyces pactum.The conformation of 23S rRNA nucleotide A2058 determines its recognition by the ErmE methyltransferase.Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes.Cloning vectors, mutagenesis, and gene disruption (ermR) for the erythromycin-producing bacterium Aeromicrobium erythreum.Core sequence in the RNA motif recognized by the ErmE methyltransferase revealed by relaxing the fidelity of the enzyme for its target.A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.A repeated decapeptide motif in the C-terminal domain of the ribosomal RNA methyltransferase from the erythromycin producer Saccharopolyspora erythraea.Weapons in disguise--activating mechanisms and protecting group chemistry in nature.
P2860
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P2860
Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae.
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1989 nî lūn-bûn
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1989年の論文
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1989年学术文章
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1989年学术文章
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1989年学术文章
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name
Methylation of 23S rRNA caused ...... ant from Streptomyces fradiae.
@en
Methylation of 23S rRNA caused ...... ant from Streptomyces fradiae.
@nl
type
label
Methylation of 23S rRNA caused ...... ant from Streptomyces fradiae.
@en
Methylation of 23S rRNA caused ...... ant from Streptomyces fradiae.
@nl
prefLabel
Methylation of 23S rRNA caused ...... ant from Streptomyces fradiae.
@en
Methylation of 23S rRNA caused ...... ant from Streptomyces fradiae.
@nl
P2860
P1476
Methylation of 23S rRNA caused ...... ant from Streptomyces fradiae.
@en
P2093
Cundliffe E
Zalacain M
P2860
P304
P356
10.1128/JB.171.8.4254-4260.1989
P577
1989-08-01T00:00:00Z