DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation.
about
DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferationFacioscapulohumeral dystrophy: the path to consensus on pathophysiologyFacioscapulohumeral dystrophy: incomplete suppression of a retrotransposed geneDNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2A muscle stem cell for every muscle: variability of satellite cell biology among different muscle groupsNoncoding RNAs: emerging players in muscular dystrophiesTargeting mRNA for the treatment of facioscapulohumeral muscular dystrophyHomologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle DifferentiationRNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophyFacioscapulohumeral Dystrophy.β-Catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy.Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD-related gene 1 (FRG1) expression during human myogenic differentiationBiphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats.Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4.Testing the effects of FSHD candidate gene expression in vertebrate muscle development.Gene expression during normal and FSHD myogenesis.A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function.Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUX4 production.Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgeneA WNT/beta-catenin signaling activator, R-spondin, plays positive regulatory roles during skeletal myogenesisDUX4 differentially regulates transcriptomes of human rhabdomyosarcoma and mouse C2C12 cellsThe Krüppel-like factor 15 as a molecular link between myogenic factors and a chromosome 4q transcriptional enhancer implicated in facioscapulohumeral dystrophy.Immunohistochemical Characterization of Facioscapulohumeral Muscular Dystrophy Muscle BiopsiesTranscriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen.ZNF555 protein binds to transcriptional activator site of 4qA allele and ANT1: potential implication in Facioscapulohumeral dystrophyDUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes.DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy?Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesisRet function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy.Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story?Antisense Oligonucleotides Used to Target the DUX4 mRNA as Therapeutic Approaches in FaciosScapuloHumeral Muscular Dystrophy (FSHD).The cell biology of disease: FSHD: copy number variations on the theme of muscular dystrophyFacioscapulohumeral muscular dystrophy (FSHD): an enigma unravelled?Deciphering transcription dysregulation in FSH muscular dystrophy.High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity.Immunodetection of human double homeobox 4.Epigenetic alterations in muscular disordersDux4 controls migration of mesenchymal stem cells through the Cxcr4-Sdf1 axis.The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.
P2860
Q21091176-0422BFE0-9122-4713-8EBE-AB8B68ACAB81Q21195884-9DBE22F8-0874-4AB3-BC86-126FC50B2376Q21563391-9703F83F-9808-4C90-9337-34A4773E4691Q24657535-8B2769C4-914E-419B-BEDB-840905751298Q26779289-8AE756B6-6075-405A-97AB-24CC65118060Q26996781-272EEADA-CC48-4702-B66E-2B6A88C36C78Q28069201-91E3AADA-F943-472E-8EDB-67BB0D61165DQ28114835-1ED0FDB0-E87B-4A21-9980-91F72C6EC9D6Q29036117-7DAC207A-C2AA-47C3-802E-C7EE2100A6C3Q30250223-429F9F5B-739D-40C2-9BE8-66193868F55CQ30394383-5674470D-B915-45BE-9A78-EC1BD43E56F0Q33483016-128DDC41-0248-44AC-A739-FDAB7FDE6F16Q33503626-666C74E9-62A1-4BDB-9B3C-B17EE10EF255Q33615189-2021C52B-A690-4C72-9950-F4966738345BQ33861089-E3BCEF8C-9142-4EDE-8647-F029A48C4ABFQ34032716-A4E4E849-687C-463D-A714-D15F1B6A6E93Q34080484-2F707472-2732-4263-BE11-50011FD3ADA6Q34247338-EBA68523-CD31-45D1-B8AF-0F82C0A45956Q34300873-126E50E7-720A-4300-AB51-12FE32A247D8Q34695948-740CACE8-F44F-4924-98A5-DFEDCA94BDE0Q34746238-58322005-4979-4743-A001-AD88EB94BA9CQ35639668-62B6BACB-E688-4CBB-A6A2-5552130549CAQ36028441-8BFE12D5-B7FF-4EDA-AA82-070FFC2B0A1CQ36035011-A2E4133C-E0AF-4D07-9DDF-3343EF5E6FA5Q36676722-28721582-44EB-401E-BFC8-3F3DA8AD25B5Q37021520-3609A858-CEBB-4D00-B75C-62E2636DBB34Q37295318-91EC8BEA-8B54-4846-AFA5-A611F45B8215Q37368598-8F9881BA-E731-4348-B21B-9B5218F850F2Q37381271-056AE189-7F46-4E2D-A8BF-E13DA65A6DE1Q37413081-C6CA3756-454A-4FBD-921D-C7486E6DA807Q37590285-4C9CFECF-42A2-4359-AE35-7D22F39F3A25Q37724109-B3BB3113-3330-4ADC-91FB-035BFABF00AFQ37819663-F5BB1D07-6E80-497C-8FA1-E21DF771134EQ37943770-9C87341A-7785-436D-8FA4-CF5E7A4DCEC2Q38020380-AD75C775-9316-4A34-ACC9-73530B97F5CDQ41916687-87F5367A-FAFD-4743-9AE4-BED922E2FB83Q42098459-8172E131-D909-42DA-82D1-00F2F8D5B396Q42218620-362717FB-FB26-405A-AD45-92BABB108DA1Q42320215-70222AD4-EB7E-4653-9EC6-B3F3C9D6BBD3Q47764909-25182D31-0D18-471E-A9A5-7FAF62903616
P2860
DUX4c, an FSHD candidate gene, interferes with myogenic regulators and abolishes myoblast differentiation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
DUX4c, an FSHD candidate gene, ...... shes myoblast differentiation.
@en
DUX4c, an FSHD candidate gene, ...... shes myoblast differentiation.
@nl
type
label
DUX4c, an FSHD candidate gene, ...... shes myoblast differentiation.
@en
DUX4c, an FSHD candidate gene, ...... shes myoblast differentiation.
@nl
prefLabel
DUX4c, an FSHD candidate gene, ...... shes myoblast differentiation.
@en
DUX4c, an FSHD candidate gene, ...... shes myoblast differentiation.
@nl
P2093
P50
P1476
DUX4c, an FSHD candidate gene, ...... shes myoblast differentiation.
@en
P2093
Darko Bosnakovski
Rita Perlingeiro
Sarah Lamb
Tugba Simsek
P356
10.1016/J.EXPNEUROL.2008.07.022
P407
P577
2008-08-06T00:00:00Z