Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome - Wikidata - wikimedia - TriplyDB

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

http://www.wikidata.org/entity/Q39956895

about

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome Dissecting Alzheimer disease in Down syndrome using mouse models A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome The molecular basis of cognitive deficits in pervasive developmental disorders Phosphorylation-mediated regulation of alternative splicing in cancer Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort.Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice Mechanisms of tau-induced neurodegeneration.Cyclic AMP-dependent protein kinase A regulates the alternative splicing of CaMKIIδ Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.The role of DYRK1A in neurodegenerative diseases.Splicing factor SC35 promotes tau expression through stabilization of its mRNA.Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease.Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A Tau in Alzheimer disease and related tauopathies.Down syndrome--recent progress and future prospects.Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial Tau splicing and the intricacies of dementia.Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway Molecular and cellular alterations in Down syndrome: toward the identification of targets for therapeutics Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).Activation, regulation, and inhibition of DYRK1A.MNB/DYRK1A as a multiple regulator of neuronal development.Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles Regulation of alternative splicing of tau exon 10.An SRp75/hnRNPG complex interacting with hnRNPE2 regulates the 5' splice site of tau exon 10, whose misregulation causes frontotemporal dementia.Tau and neurodegenerative disease: the story so far.DYRK1A inhibition as potential treatment for Alzheimer's disease.Tau mis-splicing in the pathogenesis of neurodegenerative disorders.Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations.Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4

P2860

Q24339549-CB7E4591-F373-401B-8570-0B1B031772BB Q26745413-F7851AF4-0759-4C4D-8C1B-955EF2C022CE Q26777254-C84F283F-E153-4118-8E70-00B0C16C9FD9 Q26798983-E48013AE-CA29-432A-8D7D-5154F69F7319 Q26991872-2D8F994E-C0CF-4639-9C7B-A1989409D0B5 Q27009883-47D88EFD-5C46-402C-8B27-9653A620F92F Q27321571-54B3B4F4-B6C1-4B7C-9A1B-04496B07A828 Q27666758-070DC4AE-5323-4AD4-AAC1-F4ECFBEB2ED0 Q28541616-68EB0033-E5B0-4CC7-BC2F-AB30F5811597 Q28592850-4897BB96-75CC-4FBA-8009-2F1BA91946C6 Q30967631-F520717A-72DC-4B98-BFBA-F0748EFDF21B Q33674369-127C374D-7F74-4E2D-B241-B024EF2C7F81 Q33859830-CFAE3A82-E4C4-42C4-9B8A-92C005909FBA Q34087577-01388129-FFD7-4886-BF5A-E0CC31ACC1B3 Q34283467-3875DD10-7967-4E94-9B34-76013A6CEF03 Q34642120-B6C0FEB9-2C60-4B27-AF17-3A8C24EEAF61 Q34764464-6C029470-E8D4-41D6-84E1-549A27362BD1 Q34800508-4A3E11C5-C855-4A3A-BE47-85F1311B3F08 Q34867587-85558CD2-949B-424F-B646-FCE63B3E5FED Q34900413-9DBC19AC-050A-4225-9D7E-5E2198FFBB2D Q34953869-F7F3A0D5-F872-4655-801C-D6862465E75F Q34964947-94B31870-BCA6-4FA6-A224-09D794893504 Q34974083-845630A7-292D-450D-9D5A-72F1EF38E8BF Q35226142-8AE452A6-2238-4D23-86B0-9DEB6DEDC420 Q35721878-691B6075-1800-4A92-9DB5-2E890B9F35DC Q36010008-C5CD7912-EBF1-4278-AE4B-6897EBB4CD5C Q36111546-82F53D22-EE2D-477F-A171-9DBD8D66E695 Q37633160-4CE9CED7-A16D-43DD-A674-2B5677923EDA Q37815234-E8AA0EB8-89E4-4713-875E-E734C55B8BD2 Q37820722-466D18A1-0D8B-48B3-BC61-9E4D5FD47BFE Q38061634-72A843B6-BC3B-4AA8-94B6-67A2B8F12B2C Q38177975-FB162DDB-E3A0-4D13-A44E-9068F25BC220 Q38195811-8DE21B7F-55C0-4D5E-9425-653C6017B5AC Q38270739-9701A94E-A75E-4E00-AA1A-1385DDC60141 Q38658752-FD0E143D-BF44-484E-ACFB-400C1B4001EC Q38807264-2AFD6C00-8A44-4DFD-81D6-FA2DF2F35456 Q38843730-68F9EED7-3477-4F36-9697-5E0887BC022A Q39774444-8D077EC7-6C09-4FB0-8F7B-2231D9505A4C Q41094983-0DA25FEA-0FE6-4590-B31B-2814E4D431C9 Q41739576-32ECC3CB-7B62-412F-9320-F34C3AFB050A

P2860

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

http://www.wikidata.org/entity/Q39956895

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Increased dosage of Dyrk1A alt ...... licing of tau in Down syndrome

@en

Increased dosage of Dyrk1A alters alternative splicing factor

@nl

type

label

Increased dosage of Dyrk1A alt ...... licing of tau in Down syndrome

@en

Increased dosage of Dyrk1A alters alternative splicing factor

@nl

prefLabel

Increased dosage of Dyrk1A alt ...... licing of tau in Down syndrome

@en

Increased dosage of Dyrk1A alters alternative splicing factor

@nl

P1433

Q39956895-CA27CBE8-D92F-45F3-B91C-646E31404DC7

P1476

Q39956895-DFE1AE5C-D33A-4CDA-82E5-A531A5FDF404

P2093

Q39956895-19E69553-2FCC-4128-804F-58A635A83510

Q39956895-2A6EDA36-DD59-49B0-AD52-0433C84D0745

Q39956895-431D69DA-265E-427C-A739-516428335FFD

Q39956895-660E2F40-BF6C-4F75-8818-5A51B3946679

Q39956895-6A6BA71B-F5DE-4463-886F-1EFC473EEEB0

Q39956895-76726C4C-918B-41E6-AD82-A102421C45F3

Q39956895-81A67D39-D6A9-4B44-A539-2DB66A7796CA

Q39956895-C3BACC54-CEAB-408F-AAF1-08ADBF609278

Q39956895-D55769E9-D420-4E1B-9740-41BBA5C04625

P2860

Q39956895-0A2343B5-3609-4629-ADEB-027616465606

Q39956895-14449B0D-C78F-46DA-99B9-BB8E81593D7F

Q39956895-1CF58FEC-BEA3-43ED-9EF7-5B299A331DE4

Q39956895-1F6F0C38-BC25-4E3E-9CCE-FCC52398218B

Q39956895-2D327E99-EAA7-4FA6-9EB3-56DC1AC77B02

Q39956895-2D522362-BB66-4D51-BAD1-F20265415F30

Q39956895-382BB4BC-7906-4540-AAFC-7D95486EDDD9

Q39956895-402FDD9A-8652-4643-B092-D432100192DC

Q39956895-44497C29-E6D4-4A2F-B107-9A799644D2B5

Q39956895-44B56C27-C884-47E5-911B-30FB53C71431

P304

Q39956895-8C5D5BEB-32F0-405B-99B1-F79A341733E0

P31

Q39956895-98E19102-3A3F-463D-8924-11FF0BA12418

P356

Q39956895-A21C5DA8-9FCB-4CF2-A57E-7FE22D508681

P407

Q39956895-E5851FE5-95A4-43BC-A8A6-82B64FA4FB59

P433

Q39956895-EA7937DC-3AC8-4508-A749-5F9A89DD0B8B

P478

Q39956895-CF46064A-9E3A-4FEB-8EEA-646E4EB8246E

P50

Q39956895-1E55282F-4E90-462B-ADBB-F0D7D956AEC0

Q39956895-69A796C6-3372-4968-81C3-82FA18066B71

Q39956895-87576F3A-2237-4065-9111-7D3A08D76625

P577

Q39956895-0C5B5A13-3ECF-41B7-8605-3D9B0DE8CAE2

P5875

Q39956895-F0EF9938-27FA-4CE7-9593-2D47D59ED187

P698

Q39956895-EBE6B780-FDD3-4619-8004-E14158D40380

P932

Q39956895-3D7EDAE1-C44D-40BD-833D-7EF385DED69C

P356

P1433

Journal of Biological Chemistry

P1476

Increased dosage of Dyrk1A alt ...... licing of tau in Down syndrome

@en

P2093

Chunlei Zhou

http://www.w3.org/2001/XMLSchema#string

Fei Liu

http://www.w3.org/2001/XMLSchema#string

Jerzy Wegiel

http://www.w3.org/2001/XMLSchema#string

Jianhua Shi

http://www.w3.org/2001/XMLSchema#string

Jianhua Zhou

http://www.w3.org/2001/XMLSchema#string

Khalid Iqbal

http://www.w3.org/2001/XMLSchema#string

Tianyi Zhang

http://www.w3.org/2001/XMLSchema#string

Xiaosong Gu

http://www.w3.org/2001/XMLSchema#string

Yu-Wen Hwang

http://www.w3.org/2001/XMLSchema#string

P2860

The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)

Tau pathology in Alzheimer disease and other tauopathies

A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate

Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA

The MNB/DYRK1A protein kinase: genetic and biochemical properties

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

P304

28660-28669

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M802645200

http://www.w3.org/2001/XMLSchema#string

P407

P433

42

http://www.w3.org/2001/XMLSchema#string

P478

283

http://www.w3.org/2001/XMLSchema#string

P50

Muhammad Omar Chohan

Inge Grundke-Iqbal

P577

2008-07-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51431176

http://www.w3.org/2001/XMLSchema#string

P698

18658135

http://www.w3.org/2001/XMLSchema#string

P932

2568927

http://www.w3.org/2001/XMLSchema#string