Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.
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The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assemblyCLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelityPharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageUBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exitAPC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachmentNek4 status differentially alters sensitivity to distinct microtubule poisonsActivity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancerAntiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule PoisonsIntegrating Multiscale Modeling with Drug Effects for Cancer TreatmentTargeting the Mitotic Catastrophe Signaling Pathway in CancerIntra-tumor heterogeneity of cancer cells and its implications for cancer treatmentHitting the brakes: targeting microtubule motors in cancerGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsAndrogen receptor on the move: boarding the microtubule expressway to the nucleusCentrosomes, chromosome instability (CIN) and aneuploidyDNA damage associated with mitosis and cytokinesis failureInhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cellsThe 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cellsIntravital FRET imaging of tumor cell viability and mitosis during chemotherapyStage-Specific Changes in the Water, Na+, Cl- and K+ Contents of Organelles during Apoptosis, Demonstrated by a Targeted Cryo Correlative Analytical ApproachDynamic rendering of the heterogeneous cell response to anticancer treatmentsTime-lapse imaging of neuroblastoma cells to determine cell fate upon gene knockdownPlk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell linesMultipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cellsFine tuning chemotherapy to match BRCA1 statusCdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrestSpatiotemporal regulation of the anaphase-promoting complex in mitosisBCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal CancerA screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compoundsAn intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitorStochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrestA time-series method for automated measurement of changes in mitotic and interphase duration from time-lapse moviesTrichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cellsIdentifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discoveryHSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancerCDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following MitosisEfficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301Cell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer CellsDifferent cell fates after mitotic slippage: From aneuploidy to polyploidyA chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
P2860
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P2860
Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Cancer cells display profound ...... exposure to antimitotic drugs.
@en
Cancer cells display profound ...... exposure to antimitotic drugs.
@nl
type
label
Cancer cells display profound ...... exposure to antimitotic drugs.
@en
Cancer cells display profound ...... exposure to antimitotic drugs.
@nl
prefLabel
Cancer cells display profound ...... exposure to antimitotic drugs.
@en
Cancer cells display profound ...... exposure to antimitotic drugs.
@nl
P1433
P1476
Cancer cells display profound ...... exposure to antimitotic drugs
@en
P2093
Karen E Gascoigne
P304
P356
10.1016/J.CCR.2008.07.002
P577
2008-07-24T00:00:00Z