Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. - Wikidata - wikimedia - TriplyDB

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

http://www.wikidata.org/entity/Q39961289

about

SIRT1 negatively regulates the mammalian target of rapamycin TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner Laforin, the most common protein mutated in Lafora disease, regulates autophagy FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade Regulation of mTOR and cell growth in response to energy stress by REDD1.Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex Amino acids as regulators of gene expression A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks PHLiPPing the switch on Akt and protein kinase C signaling FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor Rapamycin and mTOR kinase inhibitors The TSC1-TSC2 complex: a molecular switchboard controlling cell growth Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2 Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control The cilia-regulated proteasome and its role in the development of ciliopathies and cancer Characterizing autism spectrum disorders by key biochemical pathways.Growth factor signaling to mTORC1 by amino acid-laden macropinosomes.The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses Coordinated regulation of protein synthesis and degradation by mTORC1 PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth PI3K/PTEN signaling in angiogenesis and tumorigenesis Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1 The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2 Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

http://www.wikidata.org/entity/Q39961289

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

@yue

2003年學術文章

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2003年學術文章

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name

Loss of Tsc1/Tsc2 activates mT ...... rough downregulation of PDGFR.

@en

Loss of Tsc1/Tsc2 activates mT ...... rough downregulation of PDGFR.

@nl

type

label

Loss of Tsc1/Tsc2 activates mT ...... rough downregulation of PDGFR.

@en

Loss of Tsc1/Tsc2 activates mT ...... rough downregulation of PDGFR.

@nl

prefLabel

Loss of Tsc1/Tsc2 activates mT ...... rough downregulation of PDGFR.

@en

Loss of Tsc1/Tsc2 activates mT ...... rough downregulation of PDGFR.

@nl

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Journal of Clinical Investigation

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Loss of Tsc1/Tsc2 activates mT ...... rough downregulation of PDGFR.

@en

P2093

Christopher L Carpenter

http://www.w3.org/2001/XMLSchema#string

David J Kwiatkowski

http://www.w3.org/2001/XMLSchema#string

Francisca Vazquez

http://www.w3.org/2001/XMLSchema#string

Gregor Cicchetti

http://www.w3.org/2001/XMLSchema#string

Henry B Koon

http://www.w3.org/2001/XMLSchema#string

Hiroaki Onda

http://www.w3.org/2001/XMLSchema#string

Hongbing Zhang

http://www.w3.org/2001/XMLSchema#string

Kirsten Asrican

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Natalia Bajraszewski

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P2860

Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

The 14-3-3 proteins positively regulate rapamycin-sensitive signaling.

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria

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1223-1233

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10.1172/JCI200317222

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8

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112

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2003-10-01T00:00:00Z

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14561707

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213485

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