Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.
about
Ubiquitin ligase ARF-BP1/Mule modulates base excision repairProtective effects and mechanisms of sirtuins in the nervous systemPARPs and the DNA damage responseBase Excision Repair, a Pathway Regulated by Posttranslational ModificationsBase excision repairSuicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies.AKT regulates NPM dependent ARF localization and p53mut stability in tumors.Mammalian base excision repair: the forgotten archangelApurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1)Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stabilityThe XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function.Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts.p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates.Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virusRECQ1 plays a distinct role in cellular response to oxidative DNA damage.PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.The Sound of Silence: RNAi in Poly (ADP-Ribose) ResearchPotential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.Base excision repair targets for cancer therapyMonitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair.Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repairCells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS.Dovitinib enhances temozolomide efficacy in glioblastoma cells.ARF induction in response to DNA strand breaks is regulated by PARP1.Agrobacterium T-DNA integration into the plant genome can occur without the activity of key non-homologous end-joining proteins.ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damagePARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration.USP7/HAUSP stimulates repair of oxidative DNA lesionsA feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity.Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.Poly(ADP-ribose)polymerases are involved in microhomology mediated back-up non-homologous end joining in Arabidopsis thaliana.8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients.ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts
P2860
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P2860
Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Poly(ADP-ribose) polymerase-1 ...... n of DNA double strand breaks.
@en
type
label
Poly(ADP-ribose) polymerase-1 ...... n of DNA double strand breaks.
@en
prefLabel
Poly(ADP-ribose) polymerase-1 ...... n of DNA double strand breaks.
@en
P2093
P1433
P1476
Poly(ADP-ribose) polymerase-1 ...... n of DNA double strand breaks.
@en
P2093
Bethany C Woodhouse
Grigory L Dianov
Irina I Dianova
Jason L Parsons
P304
P356
10.1016/J.DNAREP.2008.03.017
P577
2008-05-12T00:00:00Z