Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.
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Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in miceThe prion hypothesis in Parkinson's disease: Braak to the futureThe synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementiaPaired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomesHeparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seedsα-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synucleinCytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregatesMechanism of Anti-α-Synuclein ImmunotherapyAlpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons DiseaseThe role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseasesΑlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's DiseaseGlia and alpha-synuclein in neurodegeneration: A complex interactionThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseLRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's DiseaseProteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson diseaseInflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?Exosomes: mediators of neurodegeneration, neuroprotection and therapeuticsAlpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivoPropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies.More than a Rumor Spreads in Parkinson's DiseaseThe contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's diseaseSpreading of pathology in neurodegenerative diseases: a focus on human studiesAlpha-synuclein spreading in Parkinson's diseaseDe novo generation of prion strainsExpression and Transport of α-Synuclein at the Blood-Cerebrospinal Fluid Barrier and Effects of Manganese ExposureInhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model fliesPassive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body diseaseA Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other SynucleinopathiesTransduction of the MPG-tagged fusion protein into mammalian cells and oocytes depends on amiloride-sensitive endocytic pathwayPrion-like transmission of protein aggregates in neurodegenerative diseasesDirect transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies.Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicityNeuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microgliaBrain disposition of α-Synuclein: roles of brain barrier systems and implications for Parkinson's disease.A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formationLys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.
P2860
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P2860
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.
@en
type
label
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.
@en
prefLabel
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.
@en
P2093
P1476
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein
@en
P2093
He-Jin Lee
Ji-Eun Suk
Jung-Ho Lee
Seung R Paik
Seung-Jae Lee
P304
P356
10.1016/J.BIOCEL.2008.01.017
P50
P577
2008-01-20T00:00:00Z