The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function.
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Discovery of mammalian genes that participate in virus infectionStructural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigenThe cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.Activation of CREB/ATF sites by polyomavirus large T antigen.Role of middle T-small T in the lytic cycle of polyomavirus: control of the early-to-late transcriptional switch and viral DNA replicationMutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain.The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradationT antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesisLessons in signaling and tumorigenesis from polyomavirus middle T antigen.The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma.Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors.Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.Activation of DNA damage repair pathways by murine polyomavirus.The molecular chaperone activity of simian virus 40 large T antigen is required to disrupt Rb-E2F family complexes by an ATP-dependent mechanism.Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformation.Polyomavirus large T antigen induces alterations in cytoplasmic signalling pathways involving Shc activation.Polyomavirus large T antigen binds the transcriptional coactivator protein p300.The retinoblastoma protein alters the phosphorylation state of polyomavirus large T antigen in murine cell extracts and inhibits polyomavirus origin DNA replication.Polyomavirus T antigens: molecular chaperones for multiprotein complexes.J domain-independent regulation of the Rb family by polyomavirus large T antigenpRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppressionSimian virus 40 large T antigen J domain and Rb-binding motif are sufficient to block apoptosis induced by growth factor withdrawal in a neural stem cell line.ATP-dependent simian virus 40 T-antigen-Hsc70 complex formation.Effect on polyomavirus T-antigen function of mutations in a conserved leucine-rich segment of the DnaJ domainDegradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication.HSC70 interactions with SV40 viral proteins differ between permissive and nonpermissive mammalian cells.Transactivation of E2F-regulated genes by polyomavirus large T antigen: evidence for a two-step mechanism.Genetic analysis of the polyomavirus DnaJ domainHuman Polyomaviruses: The Battle of Large and Small Tumor Antigens.Microscopic and Molecular Evidence of the First Elasmobranch Adomavirus, the Cause of Skin Disease in a Giant Guitarfish, Rhynchobatus djiddensis.
P2860
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P2860
The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The DnaJ domain of polyomaviru ...... ily tumor suppressor function.
@en
type
label
The DnaJ domain of polyomaviru ...... ily tumor suppressor function.
@en
prefLabel
The DnaJ domain of polyomaviru ...... ily tumor suppressor function.
@en
P2093
P2860
P1433
P1476
The DnaJ domain of polyomaviru ...... ily tumor suppressor function.
@en
P2093
B Schaffhausen
J A DeCaprio
M Ratnofsky
T M Roberts
P2860
P304
P407
P577
1997-12-01T00:00:00Z