Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells
about
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactionsAbl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinasesRegulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinasehKSR-2, a vitamin D-regulated gene, inhibits apoptosis in arabinocytosine-treated HL60 leukemia cellsSignaling pathways activated by oncogenic forms of Abl tyrosine kinase.Disruption of the Shc/Grb2 complex during abelson virus transformation affects proliferation, but not apoptosis.NF-kappaB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression.An old kinase on a new path: Raf and apoptosis.Inhibition of endothelial cell survival and angiogenesis by protein kinase ABiphasic role of TGF-beta1 in signal transduction and crosstalk.Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant.Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells.Repeated electroconvulsive seizure induces c-Myc down-regulation and Bad inactivation in the rat frontal cortex.The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.CDK-inhibitor independent cell cycle progression in an experimental haematopoietic stem cell leukaemia despite unaltered Rb-phosphorylationv-Src generates a p53-independent apoptotic signal.Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.cAMP signaling selectively influences Ras effectors pathways.Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1.In vitro-generated stem cell leukaemia showing altered cell cycle progression with distinct signalling of the tyrosine-phosphorylated rasGAP-associated p62(dok) protein.Perturbation of EGF-activated MEK1 and PKB signal pathways by TGF-beta1 correlates with perturbation of EGF-induced cyclin D1 and DNA synthesis by TGF-beta1 in C3H 10T1/2 cells.v-Abl utilizes multiple mechanisms to drive G1/S progression in fibroblasts.Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy.Raf-1 without MEK?Brain-derived neurotrophic factor exerts opposing effects on beta2-adrenergic receptor according to depolarization status of cerebellar neurons.Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase.
P2860
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P2860
Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Inhibition of the Raf-1 kinase ...... sis of v-abl-transformed cells
@en
type
label
Inhibition of the Raf-1 kinase ...... sis of v-abl-transformed cells
@en
prefLabel
Inhibition of the Raf-1 kinase ...... sis of v-abl-transformed cells
@en
P2093
P2860
P356
P1476
Inhibition of the Raf-1 kinase ...... sis of v-abl-transformed cells
@en
P2093
Weissinger EM
P2860
P304
P356
10.1128/MCB.17.6.3229
P407
P577
1997-06-01T00:00:00Z