Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis.
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Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferationPhosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loopRole of EPAC in cAMP-Mediated Actions in Adrenocortical CellsActivation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathwayProtein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropinDirect spatial control of Epac1 by cyclic AMP.Switch in signaling control of mTORC1 activity after oncoprotein expression in thyroid cancer cell lines.Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cellsEvidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.PKA and Epac synergistically inhibit smooth muscle cell proliferation.A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion.Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia.The cyclic AMP effector Epac integrates pro- and anti-fibrotic signalsEPAC proteins transduce diverse cellular actions of cAMP.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.Targeting protein kinase A in cancer therapy: an update.PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulationProstaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1.Signaling pathways involving adenosine A2A and A2B receptors in wound healing and fibrosis.Protein kinase a in cancerEpac as a novel effector of airway smooth muscle relaxation.Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells.Cyclic Adenosine Monophosphate-Mediated Enhancement of Vascular Endothelial Growth Factor Released by Differentiated Human Monocytic Cells: The Role of Protein Kinase A.The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle, and is a minor regulator of α1-adrenergic contraction.Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway.Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase.Cyclase-Associated Protein 1 (CAP1) is a prenyl-binding partner of Rap1 GTPase.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Cooperation of Epac1/Rap1/Akt and PKA in prostaglandin E(2) -induced proliferation of human umbilical cord blood derived mesenchymal stem cells: involvement of c-Myc and VEGF expression.Cilostazol enhances integrin-dependent homing of progenitor cells by activation of cAMP-dependent protein kinase in synergy with Epac1.Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke
P2860
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P2860
Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Epac, in synergy with cAMP-dep ...... for cAMP-mediated mitogenesis.
@en
type
label
Epac, in synergy with cAMP-dep ...... for cAMP-mediated mitogenesis.
@en
prefLabel
Epac, in synergy with cAMP-dep ...... for cAMP-mediated mitogenesis.
@en
P2093
P2860
P356
P1476
Epac, in synergy with cAMP-dep ...... for cAMP-mediated mitogenesis.
@en
P2093
Daniel Hochbaum
Daniel L Altschuler
Fernando Ribeiro-Neto
Guillermo Barila
Kyoungja Hong
P2860
P304
P356
10.1074/JBC.C700171200
P407
P577
2007-12-06T00:00:00Z