Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
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Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradationThe Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationUbiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3Ubc13: the Lys63 ubiquitin chain building machineSubcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-ReviewParkin Regulation and Neurodegenerative DisordersThe different roles of selective autophagic protein degradation in mammalian cellsNiclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibitionUEV-1 is an ubiquitin-conjugating enzyme variant that regulates glutamate receptor trafficking in C. elegans neuronsCrystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architectureK63 polyubiquitination is a new modulator of the oxidative stress responseA perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis.Accumulation of ubiquitin and sequestosome-1 implicate protein damage in diacetyl-induced cytotoxicityQuality control systems in cardiac agingProteomics of protein post-translational modifications implicated in neurodegenerationUCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagySelective autophagy mediated by autophagic adapter proteinsThe ubiquitin-proteasome system in spongiform degenerative disordersProtein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylationUbiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targetingIndividual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 speciesProtein misfolding specifies recruitment to cytoplasmic inclusion bodiesAggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.Copper-triggered aggregation of ubiquitin.Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infectionUbiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy.Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradationProtein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumInsulin receptor substrate 1/2 (IRS1/2) regulates Wnt/β-catenin signaling through blocking autophagic degradation of dishevelled2.Acetylation of tau inhibits its degradation and contributes to tauopathyNuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus.Parkin-mediated ubiquitin signalling in aggresome formation and autophagy.Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissuesMultiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chainsThe ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionThe ubiquitin-proteasome pathway and synaptic plasticity.IKK regulates the deubiquitinase CYLD at the postsynaptic density.
P2860
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P2860
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Lysine 63-linked ubiquitinatio ...... th neurodegenerative diseases.
@en
type
label
Lysine 63-linked ubiquitinatio ...... th neurodegenerative diseases.
@en
prefLabel
Lysine 63-linked ubiquitinatio ...... th neurodegenerative diseases.
@en
P2093
P50
P921
P356
P1476
Lysine 63-linked ubiquitinatio ...... th neurodegenerative diseases.
@en
P2093
Esther S P Wong
Han Seok Ko
Jeanne M M Tan
Juan Troncoso
Kah-Leong Lim
Michelle W L Ho
Olga Pletnikova
Shiam-Peng Tay
P304
P356
10.1093/HMG/DDM320
P577
2007-11-01T00:00:00Z