Spatial and temporal regulation of focal adhesion kinase activity in living cells.
about
Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibitionFocal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motilityPaxillin comes of ageNuclear FAK: a new mode of gene regulation from cellular adhesionsRegulation of protein kinases by lipidsFAK in cancer: mechanistic findings and clinical applicationsNovel Phosphotidylinositol 4,5-Bisphosphate Binding Sites on Focal Adhesion KinaseRole of the histone domain in the autoinhibition and activation of the Ras activator Son of SevenlessFAK dimerization controls its kinase-dependent functions at focal adhesionsPhosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changesMechanism of Focal Adhesion Kinase MechanosensingCell adhesion: integrating cytoskeletal dynamics and cellular tension.Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transferNetrin-1 attracts axons through FAK-dependent mechanotransductionSynonymous modification results in high-fidelity gene expression of repetitive protein and nucleotide sequences.Engineering extrinsic disorder to control protein activity in living cells.Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix.Integrin signaling through FAK in the regulation of mammary stem cells and breast cancerTetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cellsEngineered allosteric activation of kinases in living cells.Systems microscopy approaches to understand cancer cell migration and metastasis.Targeting Pyk2 for therapeutic interventionThe Pyk2 FERM regulates Pyk2 complex formation and phosphorylationEmerging role of paxillin-PKL in regulation of cell adhesion, polarity and migrationActivation of endogenous FAK via expression of its amino terminal domain in Xenopus embryosEnvironment-sensing merocyanine dyes for live cell imaging applicationsAllosteric regulation of focal adhesion kinase by PIP₂ and ATP.Role of focal adhesion kinase in oocyte-follicle communication.Imaging adhesion and signaling dynamics in Xenopus laevis growth cones.How focal adhesion kinase achieves regulation by linking ligand binding, localization and actionGrowth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane.Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses.Phospholipid binding to the FAK catalytic domain impacts function.Focal adhesion kinase and its role in skeletal muscle.Visualizing and manipulating focal adhesion kinase regulation in live cells.Multiple steps to activate FAK's kinase domain: adaptation to confined environments?pHocal adhesion kinase regulation is on a FERM foundation.Visualizing and quantifying adhesive signals.FERM control of FAK function: implications for cancer therapy.
P2860
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P2860
Spatial and temporal regulation of focal adhesion kinase activity in living cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Spatial and temporal regulation of focal adhesion kinase activity in living cells.
@en
type
label
Spatial and temporal regulation of focal adhesion kinase activity in living cells.
@en
prefLabel
Spatial and temporal regulation of focal adhesion kinase activity in living cells.
@en
P2093
P2860
P356
P1476
Spatial and temporal regulation of focal adhesion kinase activity in living cells
@en
P2093
Andrei V Karginov
Derek F Ceccarelli
Ken Jacobson
Klaus M Hahn
Michael D Schaller
Michael J Eck
Xinming Cai
P2860
P304
P356
10.1128/MCB.01324-07
P407
P577
2007-10-29T00:00:00Z