D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisPhosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseProtein phosphatase 1 regulates assembly and function of the beta-catenin degradation complexThe selectivity of protein kinase inhibitors: a further updateCasein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.The flaviviral methyltransferase is a substrate of Casein Kinase 1Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase InhibitorCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/εTiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neuronsCasein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activityFoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttlingExtracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain sheddingIdentification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screenExploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growthDrosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levelsNeurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1εRegulation of Alzheimer's disease amyloid-beta formation by casein kinase IDistinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCsAsymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway.Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation.Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stressProtein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions.CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction.Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation.Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor suppressor microRNAProtein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.FOXO1: a potential target for human diseasesThe hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase.Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.Ligation of complement receptor 1 increases erythrocyte membrane deformabilityRegulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2Casein kinase 1-dependent phosphorylation of familial advanced sleep phase syndrome-associated residues controls PERIOD 2 stabilityCSNK1α1 mediates malignant plasma cell survival.
P2860
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P2860
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
D4476, a cell-permeant inhibit ...... d nuclear exclusion of FOXO1a.
@en
type
label
D4476, a cell-permeant inhibit ...... d nuclear exclusion of FOXO1a.
@en
prefLabel
D4476, a cell-permeant inhibit ...... d nuclear exclusion of FOXO1a.
@en
P2093
P2860
P356
P1433
P1476
D4476, a cell-permeant inhibit ...... nd nuclear exclusion of FOXO1a
@en
P2093
Jenny Bain
Matthew Elliott
Philip Cohen
P2860
P356
10.1038/SJ.EMBOR.7400048
P50
P577
2004-01-01T00:00:00Z