Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions.
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesTwo open states of P2X receptor channelsExploring the ATP-binding site of P2X receptorsSize matters in activation/inhibition of ligand-gated ion channelsA P2X receptor from the tardigrade species Hypsibius dujardini with fast kinetics and sensitivity to zinc and copper.Characterization of purinergic P2X4 receptor channels expressed in anterior pituitary cellsRegulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsCovalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP.Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.Activation and regulation of purinergic P2X receptor channelsGating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsAllosteric regulation of the P2X4 receptor channel pore dilationIon channels and signaling in the pituitary gland.Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 ReceptorsAllosteric modulation of ATP-gated P2X receptor channelsPurinergic regulation of hypothalamopituitary functions.New structure enlivens interest in P2X receptors.Structural interpretation of P2X receptor mutagenesis studies on drug actionHeteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Roles of conserved ectodomain cysteines of the rat P2X4 purinoreceptor in agonist binding and channel gating.Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gatingP2X Receptor Activation.P2X4 activation modulates volume-sensitive outwardly rectifying chloride channels in rat hepatoma cells.Regulation of Pannexin 1 Surface Expression by Extracellular ATP: Potential Implications for Nervous System Function in Health and Disease.Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.Amino acid residues constituting the agonist binding site of the human P2X3 receptorDeciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models.P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation.
P2860
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P2860
Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions.
@en
type
label
Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions.
@en
prefLabel
Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions.
@en
P2093
P2860
P1476
Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions.
@en
P2093
Hana Zemkova
Irena Jelinkova
Melanija Tomic
Stanko S Stojilkovic
Zhaodong Liang
Zonghe Yan
P2860
P304
P356
10.1111/J.1471-4159.2007.04616.X
P407
P577
2007-08-01T00:00:00Z