Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.
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Molecular and functional properties of P2X receptors--recent progress and persisting challengesInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesExploring the ATP-binding site of P2X receptorsMolecular mechanism of ATP binding and ion channel activation in P2X receptorsPharmacochemistry of the platelet purinergic receptors.Agonist trapped in ATP-binding sites of the P2X2 receptor.Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 ReceptorsAllosteric modulation of ATP-gated P2X receptor channelsStructural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating.New structure enlivens interest in P2X receptors.Structural interpretation of P2X receptor mutagenesis studies on drug actionHeteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gatingP2X Receptor Activation.Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop.Mechanistic insights from resolving ligand-dependent kinetics of conformational changes at ATP-gated P2X1R ion channels.Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.Adenosine triphosphate regulates the activity of guinea pig Cav1.2 channel by direct binding to the channel in a dose-dependent manner.
P2860
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P2860
Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Contribution of the region Glu ...... cysteine scanning mutagenesis.
@en
type
label
Contribution of the region Glu ...... cysteine scanning mutagenesis.
@en
prefLabel
Contribution of the region Glu ...... cysteine scanning mutagenesis.
@en
P2093
P2860
P1476
Contribution of the region Glu ...... cysteine scanning mutagenesis
@en
P2093
David Watt
Jonathan A Roberts
Rebecca C Allsopp
Richard J Evans
P2860
P304
P356
10.1111/J.1471-4159.2009.06035.X
P407
P577
2009-03-13T00:00:00Z