The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.
about
CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegansAmyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPGenetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesisAmyloidosis in Retinal Neurodegenerative DiseasesUnfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic ImplicationsThe Amyloid Precursor Protein-A Novel Player within the Molecular Array of Presynaptic NanomachinesCaenorhabditis elegans as a model organism to study APP functionThe airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's diseaseInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseThe multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foesFE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.Hippocampal network oscillations in APP/APLP2-deficient miceAPP processing in Alzheimer's diseaseRole of Drosophila Amyloid Precursor Protein in Memory FormationProteolytic processing of Alzheimer's β-amyloid precursor proteinIntracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegansMultiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active ZonePancortins interact with amyloid precursor protein and modulate cortical cell migrationAltered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.Amyloid precursor protein (APP) regulates synaptic structure and functionThe structural biology of the amyloid precursor protein APP - a complex puzzle reveals its multi-domain architecture.In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing miceA 2cM genome-wide scan of European Holstein cattle affected by classical BSE.Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression.Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer's diseaseTyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative DisordersComparative transcriptome profiling of amyloid precursor protein family members in the adult cortexFunction, therapeutic potential and cell biology of BACE proteases: current status and future prospects.The secretases: enzymes with therapeutic potential in Alzheimer disease.ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone functionAn overview of APP processing enzymes and products.Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid β generationProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth.
P2860
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P2860
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
The secreted beta-amyloid prec ...... alities of APP-deficient mice.
@en
type
label
The secreted beta-amyloid prec ...... alities of APP-deficient mice.
@en
prefLabel
The secreted beta-amyloid prec ...... alities of APP-deficient mice.
@en
P2093
P1476
The secreted beta-amyloid prec ...... malities of APP-deficient mice
@en
P2093
Christian Buchholz
Christopher B Eckman
Claus U Pietrzik
David P Wolfer
Elaine Waldron
Jochen Herms
Martin Korte
Mikhail A Filippov
Sabine Ring
Sascha W Weyer
P304
P356
10.1523/JNEUROSCI.1026-07.2007
P407
P577
2007-07-01T00:00:00Z