The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool.
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Nedd4-2 and the regulation of epithelial sodium transportRole of the UPS in Liddle syndromeThe ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channelsCOMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphateUbiquitylation and control of renal Na+ balance and blood pressureENaC/DEG in Tumor Development and ProgressionVersatile communication strategies among tandem WW domain repeatsEpithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseasesVasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney developmentThe ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like diseaseComparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arraysNedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channelsDecreased renal corin expression contributes to sodium retention in proteinuric kidney diseasesA human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domainElectrophysiology of reactive oxygen production in signaling endosomesEpithelial Na+ channel (ENaC), hormones, and hypertension.Regulation of the epithelial sodium channel (ENaC) by membrane traffickingA splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila.Role of epithelial sodium channels and their regulators in hypertension.Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathwaysIon channel associated diseases: overview of molecular mechanismsLiddle syndrome: clinical and genetic profiles.Methods for stable recording of short-circuit current in a Na+-transporting epitheliumEpithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1Validation and optimization of novel high-throughput assays for human epithelial sodium channels.Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradationSystem-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC).Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum.Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity.Acute downregulation of ENaC by EGF involves the PY motif and putative ERK phosphorylation site.Coupling of epithelial Na+ and Cl- channels by direct and indirect activation by serine proteases.Regulation of Monocarboxylic Acid Transporter 1 Trafficking by the Canonical Wnt/β-Catenin Pathway in Rat Brain Endothelial Cells Requires Cross-talk with Notch SignalingDeubiquitylation regulates activation and proteolytic cleavage of ENaCSingle-channel analysis of functional epithelial sodium channel (ENaC) stability at the apical membrane of A6 distal kidney cells.WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitinationRegulation of the epithelial sodium channel by membrane trafficking.The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism.
P2860
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P2860
The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
The PY motif of ENaC, mutated ...... ilization from subapical pool.
@en
type
label
The PY motif of ENaC, mutated ...... ilization from subapical pool.
@en
prefLabel
The PY motif of ENaC, mutated ...... ilization from subapical pool.
@en
P2093
P1433
P1476
The PY motif of ENaC, mutated ...... ilization from subapical pool.
@en
P2093
Anne Debonneville
Chong Jiang
Daniela Rotin
Sandra Pribanic
P304
P356
10.1111/J.1600-0854.2007.00602.X
P577
2007-07-01T00:00:00Z