Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.
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PP2A delays APC/C-dependent degradation of separase-associated but not free securinProtein Phosphatases Involved in Regulating Mitosis: Facts and HypothesesSustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.Cohesion fatigue explains why pharmacological inhibition of the APC/C induces a spindle checkpoint-dependent mitotic arrestRegulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt.MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit.Overexpression of Separase induces aneuploidy and mammary tumorigenesis.The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation.Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes.PP2A as a master regulator of the cell cycle.BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separationShugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase.Protease dead separase inhibits chromosome segregation and RAB-11 vesicle trafficking.Structural biology of the separase-securin complex with crucial roles in chromosome segregation.Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.
P2860
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P2860
Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
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2007年學術文章
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2007年學術文章
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name
Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.
@en
type
label
Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.
@en
prefLabel
Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.
@en
P2093
P2860
P356
P1476
Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.
@en
P2093
Andrew J Holland
Franziska Böttger
Olaf Stemmann
Stephen S Taylor
P2860
P304
24623-24632
P356
10.1074/JBC.M702545200
P407
P577
2007-06-29T00:00:00Z