Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.
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Mechanism of Platinum Derivatives Induced Kidney InjuryRole of solute carriers in response to anticancer drugsImportance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts.Membrane transporters as mediators of Cisplatin effects and side effects.Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions.Oxaliplatin-induced renal tubular vacuolization.Carboplatin instead of cisplatin in combination with dexamethasone, high-dose cytarabine with or without rituximab (DHAC+/-R) is an effective treatment with low toxicity in Hodgkin's and non-Hodgkin's lymphomas.Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2).Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity.Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 yearsGenetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity.Effects of a DPP4 inhibitor on cisplatin-induced acute kidney injury: study protocol for a randomized controlled trial.Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.Contribution of tumoral and host solute carriers to clinical drug response.Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.OCT2 and MATE1 provide bidirectional agmatine transport.Endocrine and metabolic regulation of renal drug transporters.The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy VolunteersRenal xenobiotic transporters are differentially expressed in mice following cisplatin treatment.Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2Polymorphic transporters and platinum pharmacodynamicsOndansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs).Clinical overview on Lipoplatin: a successful liposomal formulation of cisplatin.Uptake carriers and oncology drug safety.Renal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state.Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomicsTransporter-mediated drug uptake and efflux: important determinants of adverse drug reactions.Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics.Comparative nephrotoxicity of Cisplatin and nedaplatin: mechanisms and histopathological characteristics.Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs.Review: ototoxic characteristics of platinum antitumor drugs.The impact of drug transporters on adverse drug reaction.Renal transport of organic anions and cations.Emerging roles of metal solute carriers in cancer mechanisms and treatment.Role of transporters in the distribution of platinum-based drugs.Oxaliplatin in the era of personalized medicine: from mechanistic studies to clinical efficacy.
P2860
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P2860
Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Differential contribution of o ...... agent-induced nephrotoxicity.
@en
type
label
Differential contribution of o ...... agent-induced nephrotoxicity.
@en
prefLabel
Differential contribution of o ...... agent-induced nephrotoxicity.
@en
P2093
P1476
Differential contribution of o ...... agent-induced nephrotoxicity.
@en
P2093
Atsushi Fukatsu
Atsushi Yonezawa
Ken-Ichi Inui
Sachiko Yokoo
Satohiro Masuda
Toshiya Katsura
P304
P356
10.1016/J.BCP.2007.03.004
P407
P577
2007-03-12T00:00:00Z