Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain. - Wikidata - wikimedia - TriplyDB

Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain.

Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain.

http://www.wikidata.org/entity/Q40126897

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Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR The role of PKC signaling in CRF-induced modulation of startle.Progress in corticotropin-releasing factor-1 antagonist development.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Corticotropin-releasing factor and urocortin I activate CREB through functionally selective Gβγ signaling in hippocampal pyramidal neurons.Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress Photo-cross-linkers incorporated into G-protein-coupled receptors in mammalian cells: a ligand comparison.Insights into mechanisms of corticotropin-releasing hormone receptor signal transduction.[(76) Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor.Pharmacological onomastics: what's in a name?Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevance A perspective on more effective GPCR-targeted drug discovery efforts.Receptor activity modifying proteins (RAMPs) interact with the VPAC2 receptor and CRF1 receptors and modulate their function.

P2860

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P2860

Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain.

http://www.wikidata.org/entity/Q40126897

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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name

Achieving signalling selectivi ...... e agonist's signalling domain.

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type

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Achieving signalling selectivi ...... e agonist's signalling domain.

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British Journal of Pharmacology

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Achieving signalling selectivi ...... e agonist's signalling domain.

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Berger H

http://www.w3.org/2001/XMLSchema#string

Beyermann M

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Bienert M

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Fechner K

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Furkert J

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Heinrich N

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Kraetke O

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Zhang W

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P2860

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function.

The CRF peptide family and their receptors: yet more partners discovered.

Ligand-selective receptor conformations revisited: the promise and the problem.

The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology.

Evidence that corticotropin-releasing factor receptor type 1 couples to Gs- and Gi-proteins through different conformations of its J-domain.

Characterization of parathyroid hormone receptors in canine renal cortical plasma membranes using a radioiodinated sulfur-free hormone analogue. Correlation of binding with adenylate cyclase activity.

Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells.

The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process.

Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism.

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851-859

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10.1038/SJ.BJP.0707293

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6

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151

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6303214

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17533422

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2014118

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