Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes
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Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?Quantitative modeling of GRK-mediated beta2AR regulationG-Protein/β-Arrestin-Linked Fluctuating Network of G-Protein-Coupled Receptors for Predicting Drug Efficacy and Bias Using Short-Term Molecular Dynamics SimulationComparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.Synthesis of Tritium Labeled (R,R)-4-Methoxyfenoterol.Ligand-directed signalling at beta-adrenoceptorsPharmacokinetics and metabolism of (R,R)-methoxyfenoterol in ratThe effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptorβ-Adrenergic receptor subtype signaling in heart: from bench to bedside.Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.The year in G protein-coupled receptor research.Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.{Beta}2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells.β₂ AR agonists in treatment of chronic heart failure: long path to translation.Dissociations in the effects of β2-adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity.Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice.Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: ligand-directed chiral recognition.Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signalingThe design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists.Gi proteins regulate adenylyl cyclase activity independent of receptor activationEnsemble of G protein-coupled receptor active states.Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.Fenoterol enantiomers do not possess beneficial therapeutic properties of their racemic mixture in the rat model of post myocardial infarction dilated cardiomyopathy.Cannabinoid receptor activation correlates with the proapoptotic action of the β2-adrenergic agonist (R,R')-4-methoxy-1-naphthylfenoterol in HepG2 hepatocarcinoma cellsStructural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening.Biased β2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery.Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptorCritical appraisal of the potential use of cannabinoids in cancer management.Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β₂-adrenergic receptorHuman Cytomegalovirus US28: a functionally selective chemokine binding receptor.Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and PathologyNovel cAMP signalling paradigms: therapeutic implications for airway diseaseConcurrent activation of β2-adrenergic receptor and blockage of GPR55 disrupts pro-oncogenic signaling in glioma cells.Stereoselective binding of agonists to the β2-adrenergic receptor: insights into molecular details and thermodynamics from molecular dynamics simulations.Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyteInteraction of fenoterol stereoisomers with β2-adrenoceptor-G sα fusion proteins: antagonist and agonist competition binding.Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor.The Effects of β (2) -Adrenoreceptor Activation on the Contractility, Ca-Signals and Nitric Oxide Production in the Mouse Atria.
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Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Stereochemistry of an agonist ...... t G proteins in cardiomyocytes
@en
Stereochemistry of an agonist ...... G proteins in cardiomyocytes.
@nl
type
label
Stereochemistry of an agonist ...... t G proteins in cardiomyocytes
@en
Stereochemistry of an agonist ...... G proteins in cardiomyocytes.
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prefLabel
Stereochemistry of an agonist ...... t G proteins in cardiomyocytes
@en
Stereochemistry of an agonist ...... G proteins in cardiomyocytes.
@nl
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P2860
P356
P1476
Stereochemistry of an agonist ...... t G proteins in cardiomyocytes
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Darrell R Abernethy
Irving W Wainer
Rui-Ping Xiao
Tian-Bing Wang
Weizhong Zhu
Xiaokun Zeng
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P304
P356
10.1124/MOL.108.051078
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2008-10-07T00:00:00Z