Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif.
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PI3K/AKT/mTOR Pathway in AngiogenesisOverexpression of s6 kinase 1 in brain tumours is associated with induction of hypoxia-responsive genes and predicts patients' survivalPRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexMammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growthNegative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesisSirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular EffectsHypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and TransactivitySignaling Circuits and Regulation of Immune Suppression by Ovarian Tumor-Associated MacrophagesThe three-layer concentric model of glioblastoma: cancer stem cells, microenvironmental regulation, and therapeutic implicationsTherapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shiftBroad targeting of angiogenesis for cancer prevention and therapyShedding new light on neurodegenerative diseases through the mammalian target of rapamycinMetabolic reprogramming in macrophages and dendritic cells in innate immunityHypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau proteinMetabolic control of dendritic cell activation and function: recent advances and clinical implicationsHuman iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arraysHypoxia-inducible factor-1α protein negatively regulates load-induced bone formationParadoxical effects of rapamycin on experimental house dust mite-induced asthmaLow dose rapamycin exacerbates autoimmune experimental uveitisGlycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.Hypoxia as a target for drug combination therapy of liver cancer.Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells.Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin.Hypoxia induces permeability and giant cell responses of Andes virus-infected pulmonary endothelial cells by activating the mTOR-S6K signaling pathway.Phase I study and preclinical efficacy evaluation of the mTOR inhibitor sirolimus plus gemcitabine in patients with advanced solid tumours.Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells.A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among CaucasiansHantavirus interferon regulation and virulence determinantsTargeted therapies for pancreatic cancer.mTOR signaling in lymphangioleiomyomatosisδ-Tocotrienol oxazine derivative antagonizes mammary tumor cell compensatory response to CoCl2-induced hypoxiaHIV-associated nephropathy: role of mammalian target of rapamycin pathway.Angiogenesis inhibitors: current strategies and future prospects.First-line Mammalian target of rapamycin inhibition in metastatic renal cell carcinoma: an analysis of practice patterns from the International Metastatic Renal Cell Carcinoma Database ConsortiummTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3Targeted genes and interacting proteins of hypoxia inducible factor-1.Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression.Virus interactions with endothelial cell receptors: implications for viral pathogenesis.mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process.
P2860
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P2860
Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Hypoxia-inducible factor 1alph ...... ) via an mTOR signaling motif.
@en
type
label
Hypoxia-inducible factor 1alph ...... ) via an mTOR signaling motif.
@en
prefLabel
Hypoxia-inducible factor 1alph ...... ) via an mTOR signaling motif.
@en
P2860
P356
P1476
Hypoxia-inducible factor 1alph ...... ) via an mTOR signaling motif.
@en
P2860
P304
20534-20543
P356
10.1074/JBC.M611782200
P407
P577
2007-05-14T00:00:00Z