about
Guidelines for the use and interpretation of assays for monitoring autophagyRegioselectivity and reversibility of the glutathione conjugation of quercetin quinone methideInterplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayersInteractions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's diseaseAutophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line.Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review.Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.Neurotoxins and neurotoxic species implicated in neurodegeneration.Neurotoxins and neurotoxicity mechanisms. An overview.DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity.Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's disease.Botulinum neurotoxin: evolution from poison, to research tool--onto medicinal therapeutic and future pharmaceutical panacea.Protective and toxic roles of dopamine in Parkinson's disease.Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease.Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers.Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases.Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin.Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity.Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction.One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity.Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's diseaseOverexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity.The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1.Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity.Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death.The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism.Copper neurotoxicity in rat substantia nigra and striatum is dependent on DT-diaphorase inhibition.Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies.Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome.Commentary: Evaluation of Models of Parkinson's Disease.Dopamine-dependent iron toxicity in cells derived from rat hypothalamus.On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation.Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome.Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival.Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line.Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome.On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease.Nitrobenzimidazoles as substrates for DT-diaphorase and redox cycling compounds: their enzymatic reactions and cytotoxicity.A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Juan Segura-Aguilar
@ast
Juan Segura-Aguilar
@en
Juan Segura-Aguilar
@es
Juan Segura-Aguilar
@nl
Juan Segura-Aguilar
@sl
type
label
Juan Segura-Aguilar
@ast
Juan Segura-Aguilar
@en
Juan Segura-Aguilar
@es
Juan Segura-Aguilar
@nl
Juan Segura-Aguilar
@sl
prefLabel
Juan Segura-Aguilar
@ast
Juan Segura-Aguilar
@en
Juan Segura-Aguilar
@es
Juan Segura-Aguilar
@nl
Juan Segura-Aguilar
@sl
P1053
H-8839-2013
P106
P1153
7004239555
P21
P2798
P31
P3829
P496
0000-0002-1018-673X