On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation.
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Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's diseaseNew insights into mitochondrial structure during cell death.Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line.The association between Parkinson's disease and melanoma: a systematic review and meta-analysis.DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.Protective and toxic roles of dopamine in Parkinson's disease.DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers.Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases.Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin.Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity.Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction.One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity.Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's diseaseOverexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity.The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1.Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death.Commentary: Evaluation of Models of Parkinson's Disease.On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease.Dopamine oxidation and autophagyAminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease.Commentary: A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease.Neurotoxin mechanisms and processes relevant to Parkinson's disease: an update.Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: implications in the neuroprotective therapy of Parkinson's diseNeurotoxins as Preclinical Models for Parkinson's Disease.β-phenethylamine--a phenylalanine derivative in brain--contributes to oxidative stress by inhibiting mitochondrial complexes and DT-diaphorase: an in silico study.A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions.Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson's Disease.Parkinson's Disease and Melanoma: Co-Occurrence and Mechanisms
P2860
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P2860
On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
On the neurotoxicity mechanism ...... nd hydroxyl radical formation.
@en
type
label
On the neurotoxicity mechanism ...... nd hydroxyl radical formation.
@en
prefLabel
On the neurotoxicity mechanism ...... nd hydroxyl radical formation.
@en
P2093
P50
P1476
On the neurotoxicity mechanism ...... nd hydroxyl radical formation.
@en
P2093
Carolina Perez-Pastene
Christian Arriagada
Claudio Olea-Azar
Eduardo Couve
Maria Jose Sanchez de las Matas
Pablo Caviedes
Patricia Castañeda
Pedro Martinez-Alvarado
Rebecca Graumann
Sergio Cardenas
P304
P356
10.1016/J.NBD.2004.03.014
P577
2004-07-01T00:00:00Z