Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation. - Wikidata - wikimedia - TriplyDB

Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.

Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.

http://www.wikidata.org/entity/Q40163109

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The hitchhiker's guide to the voltage-gated sodium channel galaxy Peptide neurotoxins that affect voltage-gated calcium channels: a close-up on ω-agatoxins A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23 Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.Targeting voltage sensors in sodium channels with spider toxins.Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.Neurotoxins and their binding areas on voltage-gated sodium channels.The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells The roles of sodium channels in nociception: Implications for mechanisms of pain Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae Recombinant expression and in vitro characterisation of active Huwentoxin-IV.Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels Palmitoylation influences the function and pharmacology of sodium channels.Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.Deconstructing voltage sensor function and pharmacology in sodium channels.Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.Sodium channel blockers for the treatment of neuropathic pain.Advances in targeting voltage-gated sodium channels with small molecules.Animal toxins influence voltage-gated sodium channel function.Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II.Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.Block of T-type calcium channels by protoxins I and II.Molecular Interactions between Tarantula Toxins and Low-Voltage-Activated Calcium Channels.Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice.The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7.Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.Ion channels as drug targets: the next GPCRs.The Na1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons

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Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.

http://www.wikidata.org/entity/Q40163109

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2007 nî lūn-bûn

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Jaime J Smith

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Kenneth M Blumenthal

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Sujith Alphy

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Theodore R Cummins

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P2860

Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels

Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

Two tarantula peptides inhibit activation of multiple sodium channels.

Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the KvAP potassium channel.

The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.

A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom.

Molecular determinants of high affinity binding of alpha-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel alpha subunit.

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.

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