SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells. - Wikidata - wikimedia - TriplyDB

SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells.

SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells.

http://www.wikidata.org/entity/Q40185026

about

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection New insights into an X-traordinary viral protein Identification and characterization of naturally occurring splice variants of SAMHD1 The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome The restriction factors of human immunodeficiency virus SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein Vpx is critical for reverse transcription of the human immunodeficiency virus type 2 genome in macrophages Animal Models for HIV Cure Research Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection Rapid titration of measles and other viruses: optimization with determination of replication cycle length HIV-1 and hijacking of the host immune system: the current scenario.Moderate restriction of macrophage-tropic human immunodeficiency virus type 1 by SAMHD1 in monocyte-derived macrophages.Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction.Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes Host hindrance to HIV-1 replication in monocytes and macrophages.Nuclear import of SAMHD1 is mediated by a classical karyopherin α/β1 dependent pathway and confers sensitivity to VpxMAC induced ubiquitination and proteasomal degradation.Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells.Mouse knockout models for HIV-1 restriction factors.HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation Gene carriers and transfection systems used in the recombination of dendritic cells for effective cancer immunotherapy.HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.HERV-K(HML-2), a seemingly silent subtenant - but still waters run deep.Dendritic Cells and HIV-1 Trans-Infection.The inside out of lentiviral vectors Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation Distinct characteristics of endometrial and decidual macrophages and regulation of their permissivity to HIV-1 infection by SAMHD1.Human immunodeficiency virus type 1 modified to package Simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells.

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P2860

SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells.

http://www.wikidata.org/entity/Q40185026

description

2007 nî lūn-bûn

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2007年論文

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2007年論文

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2007年论文

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SIVSM/HIV-2 Vpx proteins promo ...... sent in human dendritic cells.

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SIVSM/HIV-2 Vpx proteins promo ...... sent in human dendritic cells.

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SIVSM/HIV-2 Vpx proteins promo ...... sent in human dendritic cells.

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SIVSM/HIV-2 Vpx proteins promo ...... sent in human dendritic cells.

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Andrea Cimarelli

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Caroline Goujon

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Dominique Rigal

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Jean-Luc Darlix

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Jeanine Bernaud

http://www.w3.org/2001/XMLSchema#string

Lise Rivière

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Loraine Jarrosson-Wuilleme

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P2860

Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

VPX mutants of HIV-2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytes

Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection.

Functional analysis of the simian immunodeficiency virus Vpx protein: identification of packaging determinants and a novel nuclear targeting domain.

Evolution of the primate lentiviruses: evidence from vpx and vpr

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10.1186/1742-4690-4-2

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4

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2007-01-09T00:00:00Z

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6588236

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